ID   A0A267E523_9PLAT        Unreviewed;      1548 AA.
AC   A0A267E523;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=MACPF domain-containing protein {ECO:0000259|PROSITE:PS51412};
GN   ORFNames=BOX15_Mlig029702g1 {ECO:0000313|EMBL:PAA55987.1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA55987.1, ECO:0000313|Proteomes:UP000215902};
RN   [1] {ECO:0000313|EMBL:PAA55987.1, ECO:0000313|Proteomes:UP000215902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DV1 {ECO:0000313|EMBL:PAA55987.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:PAA55987.1};
RA   Berezikov E.;
RT   "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT   model organism for stem cell research.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAA55987.1}.
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DR   EMBL; NIVC01002678; PAA55987.1; -; Genomic_DNA.
DR   STRING; 282301.A0A267E523; -.
DR   Proteomes; UP000215902; Unassembled WGS sequence.
DR   CDD; cd00185; TNFRSF; 1.
DR   Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 7.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR020864; MACPF.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR   PANTHER; PTHR46967; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN,N-TERMINAL; 1.
DR   PANTHER; PTHR46967:SF2; KERATIN-ASSOCIATED PROTEIN 16-1-LIKE; 1.
DR   Pfam; PF07699; Ephrin_rec_like; 5.
DR   Pfam; PF01823; MACPF; 1.
DR   SMART; SM01411; Ephrin_rec_like; 8.
DR   SMART; SM00261; FU; 4.
DR   SMART; SM00208; TNFR; 3.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR   PROSITE; PS51412; MACPF_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..1548
FT                   /note="MACPF domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012921700"
FT   DOMAIN          171..595
FT                   /note="MACPF"
FT                   /evidence="ECO:0000259|PROSITE:PS51412"
FT   REGION          318..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          471..517
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        471..490
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        500..517
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1548 AA;  167724 MW;  98A7D4FC5F64544B CRC64;
     MHACLAAVIA IALLGFQVEA AEKDTSKTVD ANALEQYGPA VDAIADAISN SDKKTKDLLD
     DLTQSTDGQA TPLITKEILK NMLNERSAKT QKAGTRSISL QAEQGFNGFS NYQPSGWVMT
     ETVGEPDKVT EDAEDKMPVY VYPMGVGPVL MNGCTGASYP KTSKCYSSKV PGNGNTICMK
     LLDAAAYIGV GFDGRGFYKI ESRKASLVQR YCSNMAKFLG KDVPDTMNVF GIFETTAETK
     SFRSADEYMS YIRDKAGLSE QRNLFLSEAR QHGTSEASGF NLGAIGGIVG GAIGAIAGGP
     AGAALGATLG GAVGGSISSG SGESSGDSSS TTSSQSASKN SQYSQAARKQ GSTEDFFAIM
     YVSVIMYEIS LDDVKPNDIN FAALRDYMSL PESYFSVGAA SKFQDFLLRW GTHFIRSGKF
     GGQLKITKRA KTNKFASSEE FASLAETEFQ SMFSSLQSKY SQQTTRTGFL GFGGKKTTTT
     KSSSAKSESQ YRSTRNERNQ ESHSSSGSEF TQTTVEAQGG TPEIAEALVD FYTPAFKQLY
     HRWIASINDY VKPFEFKLKP IDQLFDMNMD DLFPAGNRDF GCVGSAGSKV NILTEPKTRR
     RYYLDEETYF ANNKTKTKLV KIYCKYKNQQ DFQNALKRRR LSLEKAVAAY MTEGPFPTSS
     HELKAGQPGC ESSTLAKIDV FNSNNNTLTF LQLKKSPFLI AFDLPQDIPN LLKSQAKYVM
     TYLKDRWFAT EPGHHHAHLY EGCQLEGFKP AETKICIWSI ILTYEEETGF FHIDPLDFIA
     SKRRNPNLPD WIEGTTFARA SRIEGQKGAN STAAASIPCN VRWLNSHRLD PDREENCLYF
     TAATAGDIFV IFASIPRDHT TWYYLQINMD GVTFYKAMKP QKRDYQKGMG TLGDKNLYQS
     YFLCANQANG SILMQFGKAG SNSEIGTVYS GYKFRSDSQY SRLSFYTFGA GSKSVSLMDI
     HLTKDMPQVE CLNNNYKMVD GHCILDCHKE CIDCNLAKDD TSCFQCRNVR VELWNSIGGR
     RVRTVQCLPE CPVGYQLSDS KENLCVPCQP GTFKNTTGNH NCLACAPGCF SASQATVNCM
     LCSPGNFASK PGSVQCQQCH VGTASSFNGS TSCGACSAGL FAAQRGQTEC TPCPVGQFNK
     AERQTQCQLC SAGFFADKPG QKSCSACPAG TSSAEGSVSC ANNCKRGEFS PAEGIPCAKC
     PAGSFTPSAG SVNCTSCAEG SYSSSARSAS CIPCPAGSFA DQISSTNCSQ CPAGSFSPSA
     GSVNCTFCAK GSYSSRAGSA SCTPCPRGFY QPLANQTHCK SAMPGWYVDT EDRSEQRMCP
     LGKYSGAAAS ECTVCPSGTF ADRVGSTNCS QCPAGSWSNA GSASCQLCKG GSFSVGNAAN
     CTLCPAGTFS NSSGSSECSK CPAGTYASES GSQKCEYCNL FSLSRHSGMT HCDQCPDSGS
     TFGTDTCYPN LRMRCWISFG ECEKTIDGDL DTYGTAIMSD HVPKGAEIFR TYFGYKLDRV
     SSVKGFLIWR NKKSRMSFKN LMLKLLNSVV DCTFHTTKPA LVRILNMW
//