ID A0A267E844_9PLAT Unreviewed; 674 AA.
AC A0A267E844;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Amiloride-sensitive sodium channel {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig004551g2 {ECO:0000313|EMBL:PAA57037.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA57037.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA57037.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA57037.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA57037.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA57037.1}.
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DR EMBL; NIVC01002543; PAA57037.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267E844; -.
DR STRING; 282301.A0A267E844; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR PANTHER; PTHR11690:SF248; PICKPOCKET 17, ISOFORM A; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 97..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 35..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 674 AA; 76516 MW; 71A675D453C7C05F CRC64;
MMARFRAQAS REDGAVEDFE MQGIDEDYRK AFLEDEAEQQ QPLTQQKSSA VSAKSKLPSN
NNMEGRKTSA MLFCECSSIR GMPKIARSSS SFLRRMWLSF IIGMTLVLIV SSSLAVRSYL
QYDVIVHTSD IPEFPSKFPA ITICLHRPFS QRALSLWANS SVMSPRGYNQ RLRRWAQEAI
NKTESNFSRI KQKDAVPIFY ALYYDMLEMY YQNVRYEDTR LLSHDPSVIR KCIIMTKWGE
SHFKDPCNLT DHNFSIKLFS HPKHFNCYTV EPNSEASSLD TIFLGLAVDL GPKPDYLNLQ
QGFLNDVFDQ ATGLRLVIHE PNRYPDVEQF GKNIEAGKMT ELAYTPTLWN RSNTPVKPCI
EGDAEPFEDL GRRFDYSQRE CTRMKTQRAA MERCGCIICL PGHPRPRIPG PDVAYCGTFT
DAYNRTTDDF IRFSNCYVED VQPSEDHLKP CLSRCVFSEY ETKLSVTEWG ATDWQVYWSG
KYLNDIEELQ RLMNQRDSRP EEEQQGLAPR FDDVKKRIMH YLTKENLTSV QASADQMVES
KNFAYVVLKR KGENLILKQE KQVLTLNALM SQIGGLCSLT IGLTCACIVE VVEFFYIYLT
TFRTNGQAGT AAINNDGGGG GVGASESSAG VGTHGQRTVL LPGTAPTSLD LDNAANHGDQ
RIEHRQLHQR SSQI
//