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Database: UniProt
Entry: A0A267E844_9PLAT
LinkDB: A0A267E844_9PLAT
Original site: A0A267E844_9PLAT 
ID   A0A267E844_9PLAT        Unreviewed;       674 AA.
AC   A0A267E844;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Amiloride-sensitive sodium channel {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BOX15_Mlig004551g2 {ECO:0000313|EMBL:PAA57037.1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA57037.1, ECO:0000313|Proteomes:UP000215902};
RN   [1] {ECO:0000313|EMBL:PAA57037.1, ECO:0000313|Proteomes:UP000215902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DV1 {ECO:0000313|EMBL:PAA57037.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:PAA57037.1};
RA   Berezikov E.;
RT   "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT   model organism for stem cell research.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAA57037.1}.
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DR   EMBL; NIVC01002543; PAA57037.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A267E844; -.
DR   STRING; 282301.A0A267E844; -.
DR   Proteomes; UP000215902; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR001873; ENaC.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690:SF248; PICKPOCKET 17, ISOFORM A; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        97..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          35..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..62
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   674 AA;  76516 MW;  71A675D453C7C05F CRC64;
     MMARFRAQAS REDGAVEDFE MQGIDEDYRK AFLEDEAEQQ QPLTQQKSSA VSAKSKLPSN
     NNMEGRKTSA MLFCECSSIR GMPKIARSSS SFLRRMWLSF IIGMTLVLIV SSSLAVRSYL
     QYDVIVHTSD IPEFPSKFPA ITICLHRPFS QRALSLWANS SVMSPRGYNQ RLRRWAQEAI
     NKTESNFSRI KQKDAVPIFY ALYYDMLEMY YQNVRYEDTR LLSHDPSVIR KCIIMTKWGE
     SHFKDPCNLT DHNFSIKLFS HPKHFNCYTV EPNSEASSLD TIFLGLAVDL GPKPDYLNLQ
     QGFLNDVFDQ ATGLRLVIHE PNRYPDVEQF GKNIEAGKMT ELAYTPTLWN RSNTPVKPCI
     EGDAEPFEDL GRRFDYSQRE CTRMKTQRAA MERCGCIICL PGHPRPRIPG PDVAYCGTFT
     DAYNRTTDDF IRFSNCYVED VQPSEDHLKP CLSRCVFSEY ETKLSVTEWG ATDWQVYWSG
     KYLNDIEELQ RLMNQRDSRP EEEQQGLAPR FDDVKKRIMH YLTKENLTSV QASADQMVES
     KNFAYVVLKR KGENLILKQE KQVLTLNALM SQIGGLCSLT IGLTCACIVE VVEFFYIYLT
     TFRTNGQAGT AAINNDGGGG GVGASESSAG VGTHGQRTVL LPGTAPTSLD LDNAANHGDQ
     RIEHRQLHQR SSQI
//
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