ID   A0A267E994_9PLAT        Unreviewed;       908 AA.
AC   A0A267E994;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Bromo domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BOX15_Mlig006432g2 {ECO:0000313|EMBL:PAA58143.1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA58143.1, ECO:0000313|Proteomes:UP000215902};
RN   [1] {ECO:0000313|EMBL:PAA58143.1, ECO:0000313|Proteomes:UP000215902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DV1 {ECO:0000313|EMBL:PAA58143.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:PAA58143.1};
RA   Berezikov E.;
RT   "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT   model organism for stem cell research.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAA58143.1}.
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DR   EMBL; NIVC01002406; PAA58143.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A267E994; -.
DR   STRING; 282301.A0A267E994; -.
DR   Proteomes; UP000215902; Unassembled WGS sequence.
DR   Gene3D; 1.20.1270.220; -; 1.
DR   Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR018359; Bromodomain_CS.
DR   InterPro; IPR027353; NET_dom.
DR   InterPro; IPR038336; NET_sf.
DR   PANTHER; PTHR22880:SF225; BROMODOMAIN-CONTAINING PROTEIN BET-1; 1.
DR   PANTHER; PTHR22880; FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS; 1.
DR   Pfam; PF17035; BET; 1.
DR   Pfam; PF00439; Bromodomain; 2.
DR   PRINTS; PR00503; BROMODOMAIN.
DR   SMART; SM00297; BROMO; 2.
DR   SUPFAM; SSF47370; Bromodomain; 2.
DR   PROSITE; PS00633; BROMODOMAIN_1; 1.
DR   PROSITE; PS50014; BROMODOMAIN_2; 2.
DR   PROSITE; PS51525; NET; 1.
PE   4: Predicted;
KW   Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW   Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          38..111
FT                   /note="Bromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50014"
FT   DOMAIN          233..305
FT                   /note="Bromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50014"
FT   DOMAIN          509..591
FT                   /note="NET"
FT                   /evidence="ECO:0000259|PROSITE:PS51525"
FT   REGION          183..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          340..359
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          403..475
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          495..524
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          586..858
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        340..354
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        403..454
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        495..521
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        588..603
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        604..635
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        642..683
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        687..787
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        788..813
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        816..849
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   908 AA;  97246 MW;  30BE62751A22B043 CRC64;
     MIEKSLDCAE MQQQQQRHHR FWSNQLEYIK RVALPAVMKL PNSWPFKAPV DPVKLQIPDY
     PNIVLKPMDL NTVKNRLNSG KVYQSGQDCI DDINGIFLNC FVFNKPGDDV VIMAEEVEAV
     FREKMRNYPP IEHEIPTERS AKLSPATPTA ALKRKASLSE TDAATVTPVS AASAAAVRPL
     SQLQPAGSRE LSSRAIKKPK REVVASSNGT AGGFASDEMR QCSALLRDVS SARQKSINWP
     FLEPVDVVAL GLHDYYDIVT QPMDLSTMRK KIDSGQYADR EAFAADFHLM IDNCLKYNPP
     DSEVHRLGKE LSKYFVDHYN RVFASHNATA SSGAAVSGVV SPVSSTTSPP IKTGGAVSVG
     NGRLSLADVN KVTELSVKVE QLYTQMTSCI SELRSIVAAN IVSNHHPPTS TPGQSTAKKP
     RNSGGSRQGK QQPQTAAPLT TPAPSQSTFV TPACKKASAT APRQKRASGS AGKKAAAAPT
     LSSSWEAAAQ PQFSASANGG NSVGYHQSQS APSQASRPMS YEEKRQLSLD INKLPGDRLG
     RVVQIIQQRE PSLRDSNPDE IEIDFETLQL DTLRELEAYV RSVLQASPPA PAAPPPTQPP
     QPQAQQAKPK HLSPEQQQPQ NAAKPVANSN RNKGAKSAAP AAVPPQQPPT LPLPPALPNP
     PQPAPLAQQP KEASPPKKPA APPTSAKPAT GQDSSSSDSD SSSDSSDSGS SGSASDLDAS
     SRRTATTSKA PVTHQPVPPV SQASAAQQPP HPSPWSSLLH KAPQQQTKAE SASAANTAAI
     HAFQKFQKQT ADSRKEREAM QRLQREEETR RAKATSAAAT AVSRSGGGKD APSSSVTAAA
     STSAAVPASA GQTIGGISAA ELERRKLEEK RRREAELTQT NLGLNTQEEL MNFEEEMNIG
     DNDEYNFF
//