ID A0A267E9U1_9PLAT Unreviewed; 4104 AA.
AC A0A267E9U1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=SH3 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig002032g2 {ECO:0000313|EMBL:PAA57472.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA57472.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA57472.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA57472.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA57472.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA57472.1}.
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DR EMBL; NIVC01002483; PAA57472.1; -; Genomic_DNA.
DR STRING; 282301.A0A267E9U1; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProt.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR CDD; cd00176; SPEC; 6.
DR Gene3D; 1.20.58.60; -; 14.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF435; SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 5; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF00435; Spectrin; 7.
DR SMART; SM00033; CH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00150; SPEC; 19.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 15.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 27..133
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 777..840
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 3831..3936
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 704..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1213..1247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2761..2789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3161..3184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3732..3831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3952..4104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1006..1064
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1371..1409
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1505..1542
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1704..1731
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1792..1860
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2197..2276
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2901..2935
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3272..3328
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 722..754
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1221..1238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2775..2789
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3778..3816
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4030..4065
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4072..4090
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4104 AA; 453378 MW; 31AB0D36D62B668B CRC64;
MIRHYHIAMI AEELTAGGDQ AIAKGAKSVN EALLLWCQQK TRGYANCVPV QDFHKSWRDG
MAFNALIHSH RPEAFDFAQL NPTDRLANLN HAFDIAADEF GVPRLLDAED VAVDDPDEKS
IIIYVTDLYS ALNRAKTEET GSKRISNFLN DMQNGARRAQ QYEANASGLL DWIRRKVAWL
ESRGFPNTVA GLQEEKRSFN QYLQVEKFER FGELTNLEVL LYDLQTLQRN EGHRVYTPQA
GATLEDLGQA WARLEAAEQA REAALVAELL RQLELEKRAR HFTSVMLPAR LKTLAELGSA
VASLRVGDDS LKEAEDAWER LLRVQSAIHN QEAIRFEPFY KAAQRLIEEN YHDKAVVARH
RDDVSARWAG LTEAFAEKEA ALRPYAEMAS AAKEVEVLRA QLQALRESVT SCDTGTDLMS
CENFLARHRI SEQELIALHE QVNRIAGRAR RLCDGRTTGA PAMSLSQKLM ALEEDYQGLL
QAFADRRRRL ETARDFLQLI RSCEDEDSWL AEKLAGLGRL QQQSADGHGD LRAARRFVSR
LQTEEAEIEH RQAVKFAHLC STCESAQLQD GADNCSDIDD GDKVAVQTAK QRQQAVSDWL
SRLRSGWRDL RRLLHACQAD AAQRLDAQQF FASAGEADDH MAGVAPLLAG RDVGHDAGSA
AALLKRHQYL RKELQAFGSA ETTGELAGLR ETAKRLTSDG DAAAAKAAKA NDGKETTDDV
HSSLGDEEED DDFNEGEEQS AEDSAVADGD EDPLIAVEEP YEELVTEMKM QEAEEPRRIQ
RVVVSHAYQA RDPKKRDLSA GKGDIFELLQ KTNKDWYSVR DLTTNKRGFL PAIYLTEISP
TTVTVRVPRP VEVTVGVPRT RTVFKRASEL ENGAVGVRRP TFRRSAGDLH RRSRRRLSRW
RRRGQRRGRC LPESERTAIR HRMEKLDATF ADLQALATAR ERSLAQAVRQ FRFFELAEAF
NDWLAGKEAA LAADEPPYLV LANGSAAVRK RCEQHFQEMA ANKGRLDELD GLAKELLADA
AAAAKEAAAV AGSAELTAET GPAAKRADKA ANQAKSLLKD LHERWDRLNK LKIEKEKKLA
DSSSIERFAK RSQETKEQLE ERRDLLAERR DPGQNLASNA AQLAHHRHLC HELDALKARA
AELDYEGRAV KEVHPSESAF IDARLEKLAD LAELVSEMAG GRERELCERR EKLLLEAEAA
KALKRLEEAS LAGPLSPARS GTAGFAQQHQ QQRRLTSVDE PATGDDEEQQ LDQLLASTEA
LEQSLDAQLA AAGAPRDPQL LALRQRLRAK RGALTDEVQR RRRERQTEAT ARRFLRDADR
AAAGLAAWQR RLAGLRSTQE VDAAASAGLE PLSQRVADLT ARWESAQSPR TELAQEDRQK
VESRLATANE ALASARAATE RRRRELRDAA ELADFDVAAD ELAEWLAEKR PSVEDRSHRK
AGGDIDRRRM RHRAFEAEMA AQAPQLEKLR KAAQQLQAKG HPDAQEALNR LEEVESLWSS
IETAAAEKGT ELDEAQKERQ LMERLEAVVE QTDRLAKEAA RAPVVEDERS ARAQQERQEY
LEERLAQCAV QTAELAQLAK ELAGRGHYNS EAILAAVGKQ EAACDSLAPQ LAERRHQLDK
AEADRQLAAS LDRELLWADE RLMSAAAVAN SAKTAPPKTP EAERLLQQSQ AGLQTELATR
RAAVEKLLQQ AEAAGGGRDG GEKAKQLVEK MEKLEAVLAQ REEQLQQAAL AKQLSVERAE
SEQRLDDCAL LLVQSDELAA DVLAAAAASP LEAGDPTAAA TAADPNQQRQ AAEKALKRLA
GLEQSLADLA SAIPESAEPD DPRRRRLSEL RREAAEQRAA LEARRDRARL AAEVADAREQ
IDSHLVTAAS EEYGTDAEQC ARLRDAFDDF QATALAPLKA RVAALQTEAE TAGEADEAMA
KMAQDLGDYL RLLEHYAECR ADNLAKAAEV HEYNRDACEL MQAAEEKLLS IPSELGRDAS
ALEKYTARHY VLLQELVPLE ERLAELRDRS ASLSGRLDPD NAKLIAARQR RVEDAFDRLE
TRQQERVRQL EGAHELLALA RQRQAVKSWL DDARPEMDDL LAKLADNVAP AEAAAMAESA
DELAGQLNER LADVKMLADE GERLCDREEG EEFNEEIEKI VDDAIAMKAV LDDRLAGLER
RATAFRAVGD FADKVRQAQQ ALASVESRAA VLAPSVESAS SEQVEQLRRE LEALKVLCER
AAAQRLPACR DSAAAANALA PGVLAEEERR SIETRLASLE AQAERASARI EAALSALICR
SDYLDYVTAD AEINDLIGSQ LARVAAVSAD AKEADDRRRR PQQLLRLQDF KDAADAQRDR
VERHLQRGRT MSGPAAELAE ATGAAWDRLS AAFEERAQAL ETARSLLRLL ADCERAENAL
LEVKPLLDAY QATGGEATEE ADAFLYDALL QLPVDQERID ALLADAAALS SSAAAASSGD
TADPEVAAAA SRAKKVAQSW SESRPRLDQC RQELDAKVRY HRFRRAGDEL DRELDRLGEL
LDADDAAVSE GDSASVADRI QRNCRVRDTE AKKLAGLLAK MTELRDEFDA AGIYPQAGAA
CKRLSERLEA LRRRCDQRDR RLQDERRCAD VADGVRAFCD WAADFADRRL AEEEAAGAVA
AQTVEEAERR LALNRDRRTE LERRLAEAAK LRLRAADLAT ASTVAAADGE GGGGGIDFAM
ALKEPREQLE AARLRLRQRF ERHSEILSGD AACAQLAERV ASVGRSLHSL ESRLSEAAAT
AAAAVADDED DPSPTLTLEP STSISASTAA SELRQLRDRL AECQEACDAL PPGGRHAAAV
ADQLSNERRR CDVVAALVDA AAKRHAAGDR LAAYLQHCDN FRLRLEARLL RLDVDDSAAA
AAEEAEDSGD DDASRRGTER LETLLAEVRG YSRQLDSLAE EGDQLTEALD SAMARRAVSD
RMEQLRKLHG EAVERCSQRL SRARRAYSIR QLLQRCRDLD RFCRTVNEAV ELSVAAVAKG
GKGGGGLGRA KQAQKELAGL LADLEARGDA LKEAEAALAE LLDRGGDGDE KVDEGVATCR
LVVERLRRRF DALRRLLRAH GAGLGRAVRL LHYLVESEDE AAWLEGRTAA LAGTDVGRSS
ADVQRLSRRL RRSQEEADNR RPLVAALLDA GKALLAQTEE SFDSAGEKAA TAATGDLDDD
EEEVDEESAR MWREFRASDT RRCTERLRTA LAALDRALER RRGLLADAER LFAYLDELGE
LRAWIEDRLA GLTALETAVA EADDDSACLA RAKTTEALLA DAETAAERVK ELAATAKLLD
HDMVDERQAE AKRLSDSLIS RLKQLKRRLE ETLTFFEFSE QVEELQAWLR RQEAALRSIE
PGTDEESCER SADRCAGIRA ALRQRQPQLD QLDARLQSLQ AEKNCRLESA RTMRDRLQTQ
LAGVHLAAKD LAKTLHDSRR IHRLLYEAAS LHEALQEKLR EVESLASYGA GPVPTEELLR
RLAMLTDSEF KPLAARRDDL GRRSRLLTEE FKGTDAEQVI RDDVSAVERL WQELSQAAEA
KRRDLLQAKE AHASLAKFAD LLPALQALLA DILAEELARD FKSALEQVDR SSQRAKDVKR
RDLQAQDFAR SVARWSRECP ASLAEHLAER VQAVNRQLEL VQSTHRRRHE IYLENADIRK
VLERCDGLDR WLDEFGREFE QCAPAFDGPA AEQLEARGRR SDELTALLLA QAPRVEALRE
LTLLERRFQE QQRAEAEQNK GAAASAKRTM SAAHSELTAG LLRRQTMKAK EQEEQQRLQK
QQQQQQQQSP SGKARPQSVG NSGKIGNRTF STKKQRGSGG GGGGRLSDLM PPSIEGELEA
RQELQSGGVK NPARKWKKRY AALCGHLLAL FKDKTAYNTG DRALHSLVIY AAQCETDSEH
RNSLRLQLKD GSLYLLMLPS NQDCLAWRGQ IKFRAGLDPS RQLVEEELQA PVEEPAAAPA
VPAAMATEEA ENDETEVTES LSSEIDSQPV AELTEDDAVP PLKSQNAVPT GGTAATVGKK
IEEKKSSGKA EAAATSTQSL PRISVTAEAS TAGGPSSSAT LSAAAMSSAA GKDKKKSSTS
SGSSLFRMFS SGRSKKKEKE KEKN
//
