ID A0A267EAD7_9PLAT Unreviewed; 819 AA.
AC A0A267EAD7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN ORFNames=BOX15_Mlig018070g1 {ECO:0000313|EMBL:PAA57672.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA57672.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA57672.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA57672.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA57672.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA57672.1}.
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DR EMBL; NIVC01002459; PAA57672.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267EAD7; -.
DR STRING; 282301.A0A267EAD7; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR CDD; cd15293; 7tmC_GPR158-like; 1.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR043458; GPR158/179.
DR PANTHER; PTHR32546; G-PROTEIN COUPLED RECEPTOR 158-RELATED; 1.
DR PANTHER; PTHR32546:SF26; SMOG, ISOFORM D; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..819
FT /note="G-protein coupled receptors family 3 profile domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013102860"
FT TRANSMEM 403..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 471..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 510..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 581..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 616..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 646..668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 401..679
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 770..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 779..794
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 819 AA; 92296 MW; 4A53387D9954436E CRC64;
MLNLLPCLPL ILLLPVASAS TKYLDYYNKI PADYLAEFEQ QDRFSALNRF VKDVAASPGL
ACSDGRSHFP LAAFRLSPAA ADAVPDAGMS YKGFDQSKRA GLSMANLLSY MYQLADSQPS
KWFQKTGDQA FWYSIVSSVV ASDEKVFGCY AVLFDGKGRL NETVPHAFRN DSISRVVTVD
SYSKTVSIQA DSVGFEWLKY HHDNRERLLA QIRRRVGHSI VPNSKHNLMP FTSKLLKQFG
GQVKVVTEAE SFWTPPAFAC QFGRWLVSYA VPFLNSGTAD QLDIGGWVVL QFELERVEIN
QCRNESTFRS LYANNVCNQG TTECVHIPDQ GLSDTNFYCK CRRYFHHGNF SGEQVRMQYL
LHRKGSASNY SSLECGPCPA ECPGSCATNG DCLIKHDLDI LRALPLVIQT FLMTVCVLVA
AIVFKTRRNR VIKAAVWILL EIFILGVTIL YLTVFLMYLN PTYEICFIIP WFREIGFTIT
YGTLLVKVYR VLCGFQSRKA HRVHVRDRDL LKYLAGIVAV AVGFMAAWTA ATLDHSRRLH
GTLESLNCSS ADQLSGQLIL EDGKVRKEDK ELSFRVCAVG YWDAVCAAGE LVFLLLGLFY
CYCVRSAPSD YSETRYITAA FISELVCSLA YHVIRHVIWD RTHPDYVYLM YFARCHLTVT
VTAALVIVPK LWYVHSPPKN AGNNRSLMYS QVDANLGEPM NPMAIAANGD LDAPEINISD
MDPEDIRAEL KRLYTQLEIF KTKVMRKENP HISKRKGGRK QTHRRFSLQP FYHKHSHKQP
AVSVQEEEIS KVSEDSSNSL EGQELERSMA KDSGGAKNV
//
