ID A0A267EAG9_9PLAT Unreviewed; 434 AA.
AC A0A267EAG9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|Pfam:PF00078};
GN ORFNames=BOX15_Mlig007576g1 {ECO:0000313|EMBL:PAA57867.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA57867.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA57867.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA57867.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA57867.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA57867.1}.
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DR EMBL; NIVC01002439; PAA57867.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267EAG9; -.
DR STRING; 282301.A0A267EAG9; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF13975; gag-asp_proteas; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000215902}.
FT DOMAIN 206..342
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|Pfam:PF00078"
SQ SEQUENCE 434 AA; 48997 MW; 16253161467A4122 CRC64;
MEKCEEDQCN KIFSMITSKQ RILHTVSING TSVEMVFDTG ADASLVSKHS FEQLSQRTDV
MPVDRTFKDY QGCAVPLFGK SIVTVQFNSI TTQLPIFIVD QPGALNIYGL EWMHALEPHL
NIYQVTHFEA HLVLKDEARP VFLKPRPIPY GIRESVKQEL DCLESEGILK KIDQSKWAMP
IVVVRKQSGK IRICGDYKVT VNKSLCDMVS TTPCIEDVLS QLGGAKIFSV LDLTNAYLQL
PVDDASGSIL TLSTLFGLYQ PKALAYGVKQ AVANFQGYMD KLLASEKNVV SYQDNILIYG
KMEQEHDDQI NVVTRILQEN NIVVNYQKSA LKCSRVKFLG LDIGSEGISP AEDKMEAIRS
LADPRSVKEL RSFLGLAEFY SRFIKNLSTI KEPLAKLIRL NIEDTNKRYP TRNRRPPDRL
QYKKLGTLTK QSLM
//
