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Database: UniProt
Entry: A0A267EC48_9PLAT
LinkDB: A0A267EC48_9PLAT
Original site: A0A267EC48_9PLAT 
ID   A0A267EC48_9PLAT        Unreviewed;      1124 AA.
AC   A0A267EC48;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
DE   Flags: Fragment;
GN   ORFNames=BOX15_Mlig000379g1 {ECO:0000313|EMBL:PAA58966.1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA58966.1, ECO:0000313|Proteomes:UP000215902};
RN   [1] {ECO:0000313|EMBL:PAA58966.1, ECO:0000313|Proteomes:UP000215902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DV1 {ECO:0000313|EMBL:PAA58966.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:PAA58966.1};
RA   Berezikov E.;
RT   "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT   model organism for stem cell research.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC       repulsion of neuronal growth cones in the developing nervous system
CC       upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367033};
CC       Single-pass type I membrane protein {ECO:0000256|RuleBase:RU367033}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the unc-5 family.
CC       {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAA58966.1}.
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DR   EMBL; NIVC01002313; PAA58966.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A267EC48; -.
DR   STRING; 282301.A0A267EC48; -.
DR   Proteomes; UP000215902; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR   CDD; cd08781; Death_UNC5-like; 1.
DR   Gene3D; 2.60.220.30; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR037936; UNC5.
DR   InterPro; IPR033772; UPA.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR12582:SF47; NETRIN RECEPTOR UNC-5; 1.
DR   PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF13927; Ig_3; 1.
DR   Pfam; PF17217; UPA; 1.
DR   Pfam; PF00791; ZU5; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00209; TSP1; 2.
DR   SMART; SM00218; ZU5; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50092; TSP1; 2.
DR   PROSITE; PS51145; ZU5; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW   ECO:0000256|RuleBase:RU367033};
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW   ECO:0000256|RuleBase:RU367033};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW   Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU367033};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU367033}.
FT   SIGNAL          1..39
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           40..1124
FT                   /note="Netrin receptor UNC5"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012176151"
FT   TRANSMEM        457..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU367033"
FT   DOMAIN          208..280
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          651..812
FT                   /note="ZU5"
FT                   /evidence="ECO:0000259|PROSITE:PS51145"
FT   DOMAIN          1059..1124
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   REGION          387..409
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          589..617
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          858..882
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        589..609
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:PAA58966.1"
SQ   SEQUENCE   1124 AA;  122226 MW;  105FFDDFE54BC756 CRC64;
     ECEAQFLVKF LQTAMKRQSR LFPPLLGWLL LIFLNSQFAT ESTALQSAES SAFSTDYGSH
     LGTAVKLLSD DEKTLPGAPR FVKEPDEQYF TSASQPAVIR CTAKHATYMT IHCNGKMLEQ
     KVEVAHDVDR PDRQNFHLAI GYDLVRQWRG DAFYCQCEAW ARIPGLGNDY RKILSSKGTV
     RLAGFESHSF QFDPLPANVP LDTSNLLMSC TPPKGKPKPT VSWLKNGHPL NLTEPDGARF
     TVDHQGQLII RPLRLEDAGN YSCVAEILGV KVRSKSASLI IHVNGGWSSW SAWSGCDPGC
     QMDTTAPSSE AVSCPEICFS QRRSRLRYCD SPEPKLGGKP CEGERSQAED CSSRCTVHGR
     WGEWSSWGIC NADCVSVRQR LCNNPPPRNG GRPCSGGSDE GVEGSSTWSA ELAGGSKQQR
     NCTGGDLCKK DSSAIPMYIN ENGKAGNSHS MVALSNIAIY VGLFVAVTVI LTVLVVIVFL
     VRKKSVALGR SSSRRRIRYN VQMNGNSSTA SSSDKEAIKL THELLLPPET GFGNNNGTTI
     KNPNVMEMSY KQLQQQQQQQ QQSSLLQSEQ ALRVHLPISQ AYHQHPAALH QSTSLQYRPP
     SSGVYSNSQL DEKCPGDEDG ISRPCSALYN ELSLGSHVTA SFVPAGICHE QLAWGSIGPS
     GGRLCLPEAG ISLTIPAGAL THCAEIFLAV SCDSRDRPHL TDRQTLLSPV VVCGSAASST
     DCPAPGRCAI VSMPHAAALR QGFWNVSVLH SRCNSGVGGG NGDVIDGGIG GWQEYLRVGS
     ESLASSGYCQ LDGASSHLMA DRLGRYCLVG ESLEGGSAVK RLSLIAFVSS AGATVAGGIG
     DFCLRLHVVP DTPDAVQSVL SQHQHQHQHQ HQHQHQHQHQ HHDFAGASVG AVGDSASAWR
     LIDSPKQLTL KDSGEPFCFC IEELSLGWRS KSKRQEVPFC HLWSGRQQEL HCTFSLEHVD
     PTRRSLLCRI VAYQQGGYSA RQTVTVTAGE NSDADADQPN RFSIECNPFA LGGGPPTSSS
     SMDSRGGCIQ IDPTNTVFRL PPKLRKALCH LLDAPNARGN DWRALTRLLG VDRYIGYFAS
     KPSPTACVLD LWEARNREDS AVRDLAEMLR VMNRPEVASL LEQQ
//
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