ID A0A267EC48_9PLAT Unreviewed; 1124 AA.
AC A0A267EC48;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
DE Flags: Fragment;
GN ORFNames=BOX15_Mlig000379g1 {ECO:0000313|EMBL:PAA58966.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA58966.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA58966.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA58966.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA58966.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367033};
CC Single-pass type I membrane protein {ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA58966.1}.
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DR EMBL; NIVC01002313; PAA58966.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267EC48; -.
DR STRING; 282301.A0A267EC48; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR CDD; cd08781; Death_UNC5-like; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582:SF47; NETRIN RECEPTOR UNC-5; 1.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT SIGNAL 1..39
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 40..1124
FT /note="Netrin receptor UNC5"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012176151"
FT TRANSMEM 457..481
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 208..280
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 651..812
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1059..1124
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 387..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 858..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PAA58966.1"
SQ SEQUENCE 1124 AA; 122226 MW; 105FFDDFE54BC756 CRC64;
ECEAQFLVKF LQTAMKRQSR LFPPLLGWLL LIFLNSQFAT ESTALQSAES SAFSTDYGSH
LGTAVKLLSD DEKTLPGAPR FVKEPDEQYF TSASQPAVIR CTAKHATYMT IHCNGKMLEQ
KVEVAHDVDR PDRQNFHLAI GYDLVRQWRG DAFYCQCEAW ARIPGLGNDY RKILSSKGTV
RLAGFESHSF QFDPLPANVP LDTSNLLMSC TPPKGKPKPT VSWLKNGHPL NLTEPDGARF
TVDHQGQLII RPLRLEDAGN YSCVAEILGV KVRSKSASLI IHVNGGWSSW SAWSGCDPGC
QMDTTAPSSE AVSCPEICFS QRRSRLRYCD SPEPKLGGKP CEGERSQAED CSSRCTVHGR
WGEWSSWGIC NADCVSVRQR LCNNPPPRNG GRPCSGGSDE GVEGSSTWSA ELAGGSKQQR
NCTGGDLCKK DSSAIPMYIN ENGKAGNSHS MVALSNIAIY VGLFVAVTVI LTVLVVIVFL
VRKKSVALGR SSSRRRIRYN VQMNGNSSTA SSSDKEAIKL THELLLPPET GFGNNNGTTI
KNPNVMEMSY KQLQQQQQQQ QQSSLLQSEQ ALRVHLPISQ AYHQHPAALH QSTSLQYRPP
SSGVYSNSQL DEKCPGDEDG ISRPCSALYN ELSLGSHVTA SFVPAGICHE QLAWGSIGPS
GGRLCLPEAG ISLTIPAGAL THCAEIFLAV SCDSRDRPHL TDRQTLLSPV VVCGSAASST
DCPAPGRCAI VSMPHAAALR QGFWNVSVLH SRCNSGVGGG NGDVIDGGIG GWQEYLRVGS
ESLASSGYCQ LDGASSHLMA DRLGRYCLVG ESLEGGSAVK RLSLIAFVSS AGATVAGGIG
DFCLRLHVVP DTPDAVQSVL SQHQHQHQHQ HQHQHQHQHQ HHDFAGASVG AVGDSASAWR
LIDSPKQLTL KDSGEPFCFC IEELSLGWRS KSKRQEVPFC HLWSGRQQEL HCTFSLEHVD
PTRRSLLCRI VAYQQGGYSA RQTVTVTAGE NSDADADQPN RFSIECNPFA LGGGPPTSSS
SMDSRGGCIQ IDPTNTVFRL PPKLRKALCH LLDAPNARGN DWRALTRLLG VDRYIGYFAS
KPSPTACVLD LWEARNREDS AVRDLAEMLR VMNRPEVASL LEQQ
//