ID A0A267EC63_9PLAT Unreviewed; 1207 AA.
AC A0A267EC63;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Dynamin-binding protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=BOX15_Mlig016976g1 {ECO:0000313|EMBL:PAA59170.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA59170.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA59170.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA59170.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA59170.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA59170.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NIVC01002290; PAA59170.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267EC63; -.
DR STRING; 282301.A0A267EC63; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00174; SH3; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 5.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR22834; NUCLEAR FUSION PROTEIN FUS2; 1.
DR PANTHER; PTHR22834:SF20; NUCLEAR FUSION PROTEIN FUS2; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 5.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50044; SH3-domain; 5.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50002; SH3; 5.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 8..71
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 78..147
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 166..226
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 276..339
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 598..776
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 829..1046
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 1142..1207
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 440..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..494
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PAA59170.1"
SQ SEQUENCE 1207 AA; 130036 MW; F64A33D9C76D3C75 CRC64;
HALPAAPTMP RLYVASHAFA PDRPDEDLEL RPGDCVALLD RLPGCDWGRG VSLATEAEGI
FPMNFAAELP GGQLNIGSGQ RLYRCGYSFP ADAAGDLAMS PGDVILGLEA IDSNWWLGRR
LCPVQRNGRS DPPTGAFPLT HVKDVTHLVK PEMDSADEAS SSLRVDQPRQ AVATKSVAAA
HIGGELSFNQ GDRLIVTRRI DEVFLEGYCG DRFGMFPADY VRFLDETDQT VDRFDCSNAD
ESAAAVGGGA GFAEEATMAQ ETSKLHSGYT RSGSQELQSY GQVKYPFVAQ ETGELTVMPD
TIVYLLGHQD HEWTYCMVDS DYGPQRGLVP TAYIDIIVDC DHGARTLMSE PQPPLAKLSE
SASALVEEED AARREPAFHL SSLDSKEAKR LSLDQAISAE LSLAKASGAE RVRALPDSDK
AAMALRLMAQ TENLLLQSSA AQQASLPPPL PLPPVQPPPV PPPPLPRQPP PMPPLPLPPP
LPPAVSPSRV APSVPPKPSD SLVRSRLGSS DAAAAVAVTE DQIVRDLRSR INSLDKQGED
REASATAAAT AAAAANVALK DGGAGGSGER AYLTDILAGL EPTPVDAVSE EAAKRRRRWT
HVFNELTATE RAFNSDMTAL AEAFLRQPGA ADRPAGFPAE SLFAHLEEVE AVSAGLLSDW
ERQPADPGAA LLRRQAELES AYSGYCGRQR ESLELATRLS GHPQFGPYMS AKAAKLMPNS
RFDLSALLIK PVQRVTKYPL LLNDLVQSAE PGSAEADNLV AAFQLVKSLV HHINESQRTR
ELLNRYLYSN RRGGGGGGDG AGGQNDSGES GWRLSHALTK KSGRLSQMIS AGLGLAESTQ
DEELERCVAN FKQCKRCVRV LLDRCEALGA AMRHSLTDLV GLAQSLWAFS SECGGLEQAN
QLLSVQRALL QDYTGQCLAD LDSEVLAPLN ELLGCYRGPA TLIIKCNSKR LDYDKLRGQS
AKKAELTARE REDLGTAERT YAALRDRLKE ELPQLCRLSV TFLQHSLARF ARLHQGFTRR
SLDSLNSAPL PGLEATFADR CAADLADVTD RLAALRIAPD GFSPRVAGGV GATWTSESAV
ASAAEPEQQQ QPQTQSTTIW YVDPFPLLNT ELEPMTAETA AADTPIPAAR RQPSSEASQQ
QQPDPVARVI YAFCGRNPNE LTVVPDELVR VRAFCDQSGN SDWWLVTKTD ASALSGYVPA
AYVAREA
//
