ID A0A267ED55_9PLAT Unreviewed; 1746 AA.
AC A0A267ED55;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=TRPM SLOG domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig017223g1 {ECO:0000313|EMBL:PAA59515.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA59515.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA59515.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA59515.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA59515.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA59515.1}.
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DR EMBL; NIVC01002256; PAA59515.1; -; Genomic_DNA.
DR STRING; 282301.A0A267ED55; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR PANTHER; PTHR13800:SF1; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 785..803
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1009..1030
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1137..1159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1171..1199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1253..1277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 130..398
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 1009..1288
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 821..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1390..1421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1472..1525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1633..1652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1688..1746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1489..1525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1689..1703
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1746 AA; 191669 MW; A7A09022D9B766BB CRC64;
MATNCGSIGR VGSLTNGVGG NEPDGDLVSV SSSQEEVWIE TNIRKRECVR FAPASLTTGA
QQQQQQQLCQ CGRAFAQHHS LDPGLAVGSM AAAGGGAASA AWRPETHTVS SPTDAYGVIE
FASGPHPTMA RYIRVAEDTD PALLLHVLTN VWRLPLPKLV LSVHGGMQNF ELQPRLRQLA
LSGLLKAAKT TDAWLISTGL DNGVSRLVGE AIGEEARARE NRVCAIGIAP WGVIRDRDQL
LGRSRTCKYF AISSAGKSLS VLNRYHSYFL LVDDGRCGSY GTESQLRRNL ERYLCSLRLC
KSHFGVGLDR VPVVATLLEG GASAFRLLLD LTLGSPPVPV VVCDGSGRAA DILAFVHKYS
DQVLSQPDLS NQLVDLIESK FHLSRAQSVA VIQELRMCFL GPGRLLIFVF RPGEGVFKDL
DDAILTSLLT SQRLSRASQL KLTMAWDRMD LARSHLFQYG QDWKPADLDR AMMEALMNDR
IDFIRLFLEW GVNVQRFLTR IRLEELYSFC LYSDESKSGH DKHLRRLLKR TLPKYSGRHR
HRLSLYIVGR LIQELIGGGY THEYTRRYAN SKAPLAPWSA SESKDVALGT AAAASPSAAA
PSTAAATPAN ANVFFSGLRN VRSRLGINPE EEPPLQLKQS DFRFPYSDLM TWAVLCRRYT
LAWFFLQCGE DSTAKALYAA ALLRAIAARV DEDVQSEYHL ELADWADKYE TEALAMLDHC
HRFDPRRARR LVTYRLAEFG GHTCMSLAYT SRSMRFLSHA CPQVILNDLW YGGIRESGQL
TGLRVVLLCG ILAACPPAFF LLLRAKFLSF KSLAELRDQP QTREEFDEFA QQEGSDSGDE
ASEAEQAART AAAAAAGAPA QAFVEPESLR NLMRSMPADS LGDKLRRMES PDVEAADADV
DGASKNPRAT EAAKAAASQD ASPARQALLS AGGDSAAQQQ QQKQAPVLHY HLEDPNRRVR
NYTYRSGVQP YGQAPPQPPV MQQQQQQQHD RLPYRMCVSE FFSAPITRYW LHLMSYAFFI
ASFLSYALVA LPQKRLLWQE VVVFAYVASY AADKVREVAF SGGRNFKTNL TVHLSDAWNV
FDLCVCAVSA VGIATRLASL WCCVYGPAVE FDFYANYSRL LGPADDPTEL ADFAVQFYLF
FCSQNIMVLA LGLWLLRVFE VLINWKHLGP YLYMVASMMG KMLPPIVIIF VPLCAFGIIR
QGIQYPGHDR FNITVVKGIL LKPYFMLYGE VYADEIDPDG WSGLESLMPL RSIVPISMVI
FLLVTVIVCI SIIIAVFNDI YHEVHEKSKQ VYKYLRFSII IEYESMPVFP PPFSLFSWLY
LLGRWLHRRL TRKEEDEDEF PDSSGIEDGR VITSLKLFLR PEEAAALQSF ESQCVQDLLL
IRTRLERGRS PGQLSELSDR QLTDDAAPPA PTPETASAAA AAAAADAATR VNDLTQRHLL
AAVERRIAAA EAAAAAAAEA ATAAAAAVAM VVGSSEQQPP PQPQPPTPQT GQDSGGQSAP
QQQRQPSIRR PLRRASSISE TPQQLSAAEA APLNILLGLR PPPDCGYTSI CDAIDIGPTL
ATAAATDASE VSVASPPRPS PLRRLDATLR DAEERERSVL GSALRRRLRQ FSITGELPEG
VGEGSAAAYD TVGNEAEDGD GREGDDGDTG EADEKASLQD IMEVALERLV DAELRDCGVD
QLQQLRLQEF DDEEDDDGGV GDEGGYEDAM AMMAAGGGPS SFDLSGDPAA CPSVDVPDEA
DEETGV
//
