ID A0A267EDW2_9PLAT Unreviewed; 624 AA.
AC A0A267EDW2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=IF rod domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig015143g2 {ECO:0000313|EMBL:PAA59755.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA59755.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA59755.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA59755.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA59755.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|PIRNR:PIRNR005546, ECO:0000256|RuleBase:RU000685}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA59755.1}.
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DR EMBL; NIVC01002234; PAA59755.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267EDW2; -.
DR STRING; 282301.A0A267EDW2; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.60.40.1260; Lamin Tail domain; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 2.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR016451; Intermed_filament_ifa/ifb.
DR InterPro; IPR001322; Lamin_tail_dom.
DR InterPro; IPR036415; Lamin_tail_dom_sf.
DR PANTHER; PTHR45721:SF12; INTERMEDIATE FILAMENT PROTEIN IFA-1; 1.
DR PANTHER; PTHR45721; LAMIN DM0-RELATED; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF00932; LTD; 1.
DR PIRSF; PIRSF005546; Intermed_filamnt_Ifb-2; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR SUPFAM; SSF74853; Lamin A/C globular tail domain; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
DR PROSITE; PS51841; LTD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PIRNR:PIRNR005546};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|PIRNR:PIRNR005546};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902}.
FT DOMAIN 102..455
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT DOMAIN 500..619
FT /note="LTD"
FT /evidence="ECO:0000259|PROSITE:PS51841"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 99..225
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 254..288
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 353..440
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 624 AA; 70820 MW; 1BF0E87AD439F109 CRC64;
MSTSSSNNAQ SMTTVKTTRY NVQTSGASGG SSLGFRGPIA SPKTVVINRT LPGVAAARDL
LDASSTMRSV NISRSFSGGG GGRSGAAVAA DVSSMLTGRE KEKRDMQELN ERLAGYIEKV
RFLEAQNKKL SNELQQLKDR WGKETEKIKL TYETELQQLR KLLEDAEKHK AEAEVRISSL
EDQLNELQVL LDEANRMHQV DRETIDKLNQ QMADYDGEIS LLRRRVAAFD EERARDQRET
KRLRDDVSRL RTDLDTETLN HINAENAAQS LREELDFLKQ VHESELKELA ILAYRDTTNE
NREFWRNEMS QALHDIQREY EVKLDSMRSE IEAQYSVKVQ EARTTNTRDN LELAHLREES
KRIKGQMTDA RNRIPELEAR NAQLERELEE LRREMEEAER ECEMTKSQLR ADLASSNATL
EEYMRELQVL MDAKLSLELE IHAYRKLLEG EEVRINQRAQ ETITQRSSTV EKTSVSVEQQ
QLPSPAAAQQ MNLVKGEMSA KTTYQRTAKG NVSIQECSPD GKFVLLENTG KKKEDIGGWK
LSRNIDNNRQ TVRYTVPMGT VLDDGQRKTV KIWARGHRPL GSGSGDLEAG ETSWGVGANI
VTSLYNMEGE ERATHNQKTV YSAN
//
