ID A0A267EE75_9PLAT Unreviewed; 613 AA.
AC A0A267EE75;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=SRCR domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig019678g1 {ECO:0000313|EMBL:PAA59853.1},
GN BOX15_Mlig019678g2 {ECO:0000313|EMBL:PAA50771.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA59853.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA59853.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA59853.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA59853.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA59853.1}.
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DR EMBL; NIVC01003568; PAA50771.1; -; Genomic_DNA.
DR EMBL; NIVC01002221; PAA59853.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267EE75; -.
DR STRING; 282301.A0A267EE75; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR Gene3D; 3.10.250.10; SRCR-like domain; 2.
DR Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR InterPro; IPR042235; ZP-C.
DR InterPro; IPR001507; ZP_dom.
DR PANTHER; PTHR14002:SF43; CUB AND ZONA PELLUCIDA-LIKE DOMAIN-CONTAINING PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR14002; ENDOGLIN/TGF-BETA RECEPTOR TYPE III; 1.
DR Pfam; PF00530; SRCR; 2.
DR Pfam; PF00100; Zona_pellucida; 1.
DR SMART; SM00202; SR; 2.
DR SMART; SM00241; ZP; 1.
DR SUPFAM; SSF56487; SRCR-like; 2.
DR PROSITE; PS50287; SRCR_2; 2.
DR PROSITE; PS51034; ZP_2; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..613
FT /note="SRCR domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011916008"
FT TRANSMEM 590..612
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..142
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 173..280
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 295..541
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
FT DISULFID 247..257
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 613 AA; 65523 MW; BAAFC538A0CD428A CRC64;
MKQLWRLLPV KLVVLSCFFI TSANSQRPVS VRLVGGSKPN LGVVEVTMST GAVGRICNLG
FDNNGASVVC AMLGYRGVTG LKVDLPPYTV GNTNTVMAIS GCPDFLEAST STWNLETACR
YVVSSFPPDC AGNGRDAAVI CTGTQTTSTP GPTLPPDFAT IAPIDCNNTI TSLRLDPGPE
EGLVLIQNGS LGGDNFGTIC AAGFSAIEAA TICRMLCRNE TANAIGMSGK YLTTAASYPV
MLSGLKCPAG ATSTNDCKHN GWGAAPSYCT PNTAVSVRCS QISLTPPPIP APFVVCHLYV
ANVFFTYTDV ASASLLSLYG TYNETTCNFT KNENSTTVWA TVPYIGCNSV QTTNATHVIY
TSMLYRNVTA VSGVYVDVPY IIPVECAIPK LKEVTAALLP DARTAPPITG GDSYTSEVKL
YRSYNARGFS SEIAPGDRLV VGSRIYARVR ETSPLNVRLT VRNCWASDKS DGTGASYYVV
RNKCATDANS VFRVDEKNIG INFAVMSFTQ TVSTQAYIFC DVTICTPTDP DERCLQTCGT
AVRRRRKRQL STENEKESSQ QPSRGPYILT AMTAMDVEAS RAASIADATL LWLMTTALVA
AVAWNTFSSV FIH
//
