ID   A0A267EFE8_9PLAT        Unreviewed;      1298 AA.
AC   A0A267EFE8;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   22-FEB-2023, entry version 17.
DE   RecName: Full=Cytoplasmic FMR1-interacting protein {ECO:0000256|PIRNR:PIRNR008153};
GN   ORFNames=BOX15_Mlig029510g1 {ECO:0000313|EMBL:PAA60176.1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA60176.1, ECO:0000313|Proteomes:UP000215902};
RN   [1] {ECO:0000313|EMBL:PAA60176.1, ECO:0000313|Proteomes:UP000215902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DV1 {ECO:0000313|EMBL:PAA60176.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:PAA60176.1};
RA   Berezikov E.;
RT   "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT   model organism for stem cell research.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the CYFIP family.
CC       {ECO:0000256|ARBA:ARBA00025790, ECO:0000256|PIRNR:PIRNR008153}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAA60176.1}.
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DR   EMBL; NIVC01002183; PAA60176.1; -; Genomic_DNA.
DR   STRING; 282301.A0A267EFE8; -.
DR   Proteomes; UP000215902; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   InterPro; IPR009828; CYRIA/CYRIB_Rac1-bd.
DR   InterPro; IPR008081; Cytoplasmic_FMR1-int.
DR   PANTHER; PTHR12195:SF0; CYTOPLASMIC FMR1-INTERACTING PROTEIN; 1.
DR   PANTHER; PTHR12195; CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED; 1.
DR   Pfam; PF07159; CYRIA-B_Rac1-bd; 1.
DR   Pfam; PF05994; FragX_IP; 1.
DR   PIRSF; PIRSF008153; FMR1_interacting; 1.
DR   PRINTS; PR01698; CYTOFMRPINTP.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR008153};
KW   Reference proteome {ECO:0000313|Proteomes:UP000215902}.
FT   DOMAIN          66..237
FT                   /note="CYRIA/CYRIB Rac1 binding"
FT                   /evidence="ECO:0000259|Pfam:PF07159"
FT   REGION          536..560
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        543..557
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1298 AA;  148615 MW;  549B2760F34ADD07 CRC64;
     MSAAQSDGQV TIVDAIRNVD LLDNLDTSDD VYNIEAAPVS LLLKHDADRN FQDRSAYVVG
     VAKYMEEAAS HAEMTELLKE GEEYAVMLYT WRSCSRALPQ IRSNEQSNKG EIHERTVEVL
     QPYAVKLMNF MLFQARAIGR FCQDVRRLCL NMRKQDFVSE AYLLTMGKML DMFAVLDELK
     NMKASMKNDY SHYKRAAQTL RRMTDPSVLQ DAQNLTMFLA EMNKIRKTLK EELQKIDSFE
     LLFAEILNTA VLMYETKQYV FPSEKHLLVK VIGFCIFLIN TSATVNVNRL DSKKRISLAK
     VDSIFKQCQV VNLYGDMSIS PFDAYVAKSD FYEPSRWPEC RSGRVSVQGA LIDALPRIRQ
     EYASLMSELA KRTNLNTTVE QGSTRSDADN RKLYDLALKA LCRLGGWNLQ VLDAFTWKLA
     NLSDLRQNPD MPKDAEDYAK AVQYNYTSAE KFALVELVSM VKSVQAILLR MESILTDAVK
     RTVYRQLQIF VHHQLVEPLR HAVKKKKEVV RSILVAIRTM AADRFEADIA ARGAPSGVST
     KTAKRSIRDD SASQQADDIR MEQRPVAPNS TQLYMVRTML ESLAGRGNSH HTLRKDVDPQ
     LLRAIEEFNS DSFFWPYLLN YTDSLQQCCD LSQLWYREFY LEMTNGARIQ FDIDMSMPWL
     LTKHLLESRS PAFMEFLLYP MDLYNDSAFF ALTRFKRQFL YDEIEAEANL AFDQLVICLS
     DHIFSYYKNL AASIHMDEAF RSEANARGAR LPLPPPVRYS VLIGQRHVSL LGRSIDLNRL
     ISQRCNKSLL ASLETAVRLF ESRDITGILE LDCLVGLARL THRLLSEAGL SLDDFDSLLS
     EANEEVSSAC GKITLHIFWE LQLDFVPQYC YNSSTNRFVR TTQSMATETV ERVPFPEDTR
     EDLLFGSSRL NKAFNSILER YRGFVGQPHF AAMCRLLGYS GIGTVVNEML KAMRGLLEGT
     MAGYVTDLRQ LMPHECKLHR FEYTSPGILG YFCAQLKPII TYPDLRTEVL QSFREFGNSL
     LVILMLEQNL TIEEVNDLKH AAAFQETLPK PFVPPPRDRG NLTGPELRRM REEESRRQLE
     RLQAKFARLS LLRVVENVFP EGHYLASVAQ DCDLLTKERL CCGLCIFETV LARLRENLEA
     SPVWTVQETP KNGVMFVDEC LEFHRIWSAI QFACCIPPGE HEFTVEELFG EGLQWAGAAL
     LVLLGQERRF ELLDFSYHLL RVNKFDQLEG SQMGFSLKAM ADRIRKFQIL NVQQLAAVGR
     YARRDQQQQQ LADAEQVRCF DCPRLPDEEG EDAADEAW
//