ID   A0A267EJT0_9PLAT        Unreviewed;      1263 AA.
AC   A0A267EJT0;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=Peptidase_M16_M domain-containing protein {ECO:0008006|Google:ProtNLM};
DE   Flags: Fragment;
GN   ORFNames=BOX15_Mlig028065g1 {ECO:0000313|EMBL:PAA61785.1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA61785.1, ECO:0000313|Proteomes:UP000215902};
RN   [1] {ECO:0000313|EMBL:PAA61785.1, ECO:0000313|Proteomes:UP000215902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DV1 {ECO:0000313|EMBL:PAA61785.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:PAA61785.1};
RA   Berezikov E.;
RT   "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT   model organism for stem cell research.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAA61785.1}.
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DR   EMBL; NIVC01001996; PAA61785.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A267EJT0; -.
DR   STRING; 282301.A0A267EJT0; -.
DR   Proteomes; UP000215902; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 7.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR032632; Peptidase_M16_M.
DR   PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 1.
DR   Pfam; PF16187; Peptidase_M16_M; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          215..351
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          368..542
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          584..868
FT                   /note="Peptidase M16 middle/third"
FT                   /evidence="ECO:0000259|Pfam:PF16187"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:PAA61785.1"
SQ   SEQUENCE   1263 AA;  143146 MW;  22D10B52E56D01A7 CRC64;
     QAITAVFRYL AMLRKLGPQE WLFEEARLEG QKALDVGLND WEYYPFVRSN ICLQRYPMQD
     LLRAHRVPCD YSPTIISDFL NLLTPDRCKV YVFEAGVNKN CPTVYGQSCP HSGAVPHSVK
     KLDPDLLAVC KADWPSPSIE FDADLGFPQP TPVDCLAESV SISQQDDSSA LSRIARRHEK
     LLALPSSDCS FRVIELTNGV QAILASRNSF GGQESNEKSL VCTTLGIGRL HDPTDFRGLA
     ELCHRLTLVG SKSTPQTFDG LNDLLLDNSC EENVEYAMGV HDDQSVYKFT VPASLIPESL
     FRLGCGLVNP EISNESVERE LLSCQFRRQI PAQDWLERCS GNLTHPYNRM AKGAQKTIRS
     YTSEELKTRL IAFFNENYSA NLLKLAIVDS RSLDELEKLV AAHFGSMRNL SINQLKISTH
     PYEGTLMGVK VRSNCLSLGR KLYMVFPLPE QTKLHLTSPD MLVSYLINNR CKGSISDCLE
     RRHLSTNVFG QLVNRGSVGF DSYCVTVFHQ NKELEMAESE NKIITIVFRY LAMLRQIGPL
     EWLYNTFRVE RRKGQTFDDE NSSTGPRWKL NPLQYYCDQL LECHMQRYPL ESLFTARYAL
     PEYSPRAITD FLEFLKPDNC KVFVSGFGTD ESHMCTFLSP DGKLCCEPDG PNFCSMEKLK
     PELIATCSAA WPSSSCEFDT ELKLPKQNLF LCSDFSLRPD ETTDQQPQGP RLLRFEAGPH
     TPAARFWFQQ DNRLQTPIVF ISVDLVTSPE PLVTDCASSV MLDIFVVLLV DQLNSLESQA
     KQVDLRLKVS RSKQGIQVCC SGYRQPLPSL VAAALSRIFE LKITEHAFRK ARRKISALEA
     QKTHKTDLCK SQLAMLLNSA CSWHWSYQDK RVAINETTLE SFMIFVQRFS SQIQLSSQPQ
     RLVSEDEDEE DKRTDAAVAV MSLWSRISLA EDEEVVEESS ALQQTLQEEQ DQQQKQQIPR
     QLFAEILVYG NATAKDAEAA SQIILNALPS PTQRTTETTF EAVRRRVYLL PSGSHHVLQL
     TISANYQRKS GCAVVLQVPK PVPTADTNMG FEDAIRQDCL FYLLIEVLQC RGEMINDPLD
     RAIKILIQRN YHAYVVTFDV VDSQHPTKIE EQVENYIEKI GDYISSLSEE SFRYCLSSME
     KSMRKEIPTT VQEQHDSHWR SITHGVLRFD RDANLAKCLD AVVGGIKKDC LLELWRSCLK
     RGSPNRRKLC IHRISRAAFP DGISEADYAD YPGTIIRNRN LFKQSLLLSP LPSVQNLRPN
     SDV
//