ID   A0A267EK85_9PLAT        Unreviewed;       208 AA.
AC   A0A267EK85;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE            EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
DE   Flags: Fragment;
GN   ORFNames=BOX15_Mlig029262g1 {ECO:0000313|EMBL:PAA61911.1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA61911.1, ECO:0000313|Proteomes:UP000215902};
RN   [1] {ECO:0000313|EMBL:PAA61911.1, ECO:0000313|Proteomes:UP000215902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DV1 {ECO:0000313|EMBL:PAA61911.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:PAA61911.1};
RA   Berezikov E.;
RT   "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT   model organism for stem cell research.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAA61911.1}.
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DR   EMBL; NIVC01001988; PAA61911.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A267EK85; -.
DR   STRING; 282301.A0A267EK85; -.
DR   Proteomes; UP000215902; Unassembled WGS sequence.
DR   GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro.
DR   CDD; cd00209; DHFR; 1.
DR   Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR   InterPro; IPR012259; DHFR.
DR   InterPro; IPR024072; DHFR-like_dom_sf.
DR   InterPro; IPR001796; DHFR_dom.
DR   PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR   PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR   Pfam; PF00186; DHFR_1; 1.
DR   PRINTS; PR00070; DHFR.
DR   SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR   PROSITE; PS51330; DHFR_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000215902}.
FT   DOMAIN          6..203
FT                   /note="DHFR"
FT                   /evidence="ECO:0000259|PROSITE:PS51330"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:PAA61911.1"
SQ   SEQUENCE   208 AA;  22940 MW;  58B1AD876C2C8A92 CRC64;
     STQQKTFSLV VAAATNGVIG RDGGLPWGYG LKTDLKFFRL VTSGPAKPSA ADSRRNLIIM
     GRRTWDSLPR KPLPNRLSVV LTRSPDELQP RLPDGVRAAA SLDAALALAD PDGPLAASVA
     EIHVIGGAAV YAEAARHPRL GRIYFTRVFD DNCIGDCRFP DSLDWSEFVQ LPPDRLPEHL
     RAEFSFDRQI EAGLEFQFTV WDRRGDLE
//