ID A0A267EKQ6_9PLAT Unreviewed; 993 AA.
AC A0A267EKQ6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011};
GN ORFNames=BOX15_Mlig029944g1 {ECO:0000313|EMBL:PAA62016.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA62016.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA62016.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA62016.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA62016.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA62016.1}.
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DR EMBL; NIVC01001981; PAA62016.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267EKQ6; -.
DR STRING; 282301.A0A267EKQ6; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
DR GO; GO:0010506; P:regulation of autophagy; IEA:InterPro.
DR CDD; cd00180; PKc; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR045269; Atg1-like.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24348; SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED; 1.
DR PANTHER; PTHR24348:SF64; SERINE_THREONINE-PROTEIN KINASE DDB_G0278901-RELATED; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00069; Pkinase; 2.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902}.
FT DOMAIN 1..184
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REPEAT 196..228
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 229..255
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 356..624
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 993 AA; 109762 MW; 4C1911E351ABDAA8 CRC64;
MKQHLEVSGP LPESTIRRYF RQIASALCYL HNHPFGPIIH KDIRCENFML TYGGFVKLID
FGFALLSGSM WPEEPLSGDP GHMAPELSGN RTYTPSSDIW ATGCVLYDMS MGTDPSVKSA
PDDADLDAIQ LNLRSFRFLR KLPVPQIQPA EKFSQELLNL HQQCMETEPA RRINAIGILL
HPFLTNVDSQ NTIDLSDPSC LHHAAASDNV QVLEAALRAG AQVNALDRSG HTALYMAVQR
GNRNAANLLL KAGGDQSYGG GEGQSPAELL ANQEAEVQKL REAFKGLESI HDLVNRDKRS
AELLTPLLQS VAERQSTDVS SERLLELVED KVDEVKLLFE RWLPNPITTS FKEVSKTKRK
SLAKGNFCDF YETETRPPNL PIVVRVLRDF NNKRIFELEK RGLEALRKTK HVNILQLLKV
HDCGNEIEMF LEKIEGQTLQ QRLEDTGPFS EINIRRYFCQ IASALCYLHN HPHGPIMHRD
IRCENIIIIH NGFVKLINFG FAMPSGSISM SNDELAEFLG YMAPEVILED KKYGRSSDVW
AAGCVLYAMS MGRSPYSYSE PDGAGSNTSQ KRLANLIDRL YGPVPEIQPA ENFSPELLDL
CRQCMEKNTA RRINATGMLL HPFLSNGESQ ILLRTEIHSW IEDVPSVIEA LSVLVNSINK
SDKDKKTAKV SGTSVAVGGG VVAIVGFALL IPSLGAALPL ALAGTGVAIA GSTTAAGAEI
IGGAVQTNEV GKAQSLIGEF RNATERLLRD QLESICSGVQ IQLMNRQSVI DLERARTEIL
QLKADVDEMI YQLQSLGILE ALQAETKETS SFEKFISKIR ELTKAKKTRN PVVELLAKIT
EPINVLLANL DDDMGAMQRG RSIDEESSTR FNQELKKSIG FFSSMLRILL FGSSKDEFHM
YVDEIKFGLR AATGGAQISL EATGIAASLA GRILGVVGSA VFTAVDIGFL VKYSTDLHRA
RQGEAAEKAQ PIICYKEIYE KLREEAMTQL AEN
//
