ID A0A267EPJ4_9PLAT Unreviewed; 462 AA.
AC A0A267EPJ4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN ORFNames=BOX15_Mlig033412g1 {ECO:0000313|EMBL:PAA63463.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA63463.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA63463.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA63463.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA63463.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA63463.1}.
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DR EMBL; NIVC01001840; PAA63463.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267EPJ4; -.
DR STRING; 282301.A0A267EPJ4; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR CDD; cd15047; 7tmC_GABA-B-like; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF20; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR01177; GABAB1RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 176..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 174..452
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 462 AA; 50555 MW; 0A364BE7D7C73F0F CRC64;
MEGSIETDTA VMDPALIETR IGPAGKTLPE LYRQFLIEYP ARLADARMKT IRGFDLRFDS
VMSAALALNQ TLQSWNYSDE MQLGNSSFKA ELMRNILKLD FIGLSGRVVF DNNGDRTSVV
MIYQLRNLSR HLVGTYDPIE NVLNWTSKFW FAGGSPPVDA PELLTRQLQL SEAGTIALTS
ASSIGIAVSI ATVAVNFHYR ELRLIKMSSP LVNNVIGAGC LMCYASCIVM AVNSHWAVST
GLCWTQTALL TIGYSAAFGA MLAKTWRVHR IFTNVKLRRV AIKDSHLFAV ILLVLATDIV
LLIAWGIIDP LTVKSVSLPS VETEDGTLIR STIDVCTCNN MTIWIATELG VKGFLLLFAL
FFAWETRTVQ VEALNDSKKI GVCVYNTTVM GLIGVVILFA LPSSSQDLKV SLIASCIIIC
SSTTLILVFG SKIFMLIKHG PSKVDDMETA MQTSAGITVP QS
//
