ID A0A267EPK4_9PLAT Unreviewed; 1673 AA.
AC A0A267EPK4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=RNA helicase {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig016460g1 {ECO:0000313|EMBL:PAA62682.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA62682.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA62682.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA62682.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA62682.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA62682.1}.
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DR EMBL; NIVC01001911; PAA62682.1; -; Genomic_DNA.
DR STRING; 282301.A0A267EPK4; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 4.10.1000.40; -; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000571; Znf_CCCH.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF234; ATP-DEPENDENT RNA HELICASE DHX40-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00356; ZnF_C3H1; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50103; ZF_C3H1; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00723}.
FT DOMAIN 250..277
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 305..332
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 621..782
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 808..978
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT ZN_FING 250..277
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT ZN_FING 305..332
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1673 AA; 187636 MW; DC308BA7C8E4A043 CRC64;
MQRPRGAASG VRRQATSSPQ ELFSVQITGL PPGVSSQSLV DRFQQSAGQF VIPPEPKQRD
KTAWCAYLNG LTENQAETFQ ERWNNKIFPG GQHSIRCKTS SSKLKGSENI QGKATQPQPM
IYNVELSGLP PNASNKFLAA TFKQSAEKFE VLPEPKQRDK TAWCAYLNDV PESEAHRFIQ
KYDNFKIGNN KFVVRCKLIF KADRRTTEDR SRVRSRVHGD SLRQQTEKLG AEASSSQSSV
STTHSETTNQ DKGILCKYNI LGTCKFDNDC KHIHMSCPME EDCDDDECCL GHPANVKTQI
GRSVGRRLVL CNLFRFGACR YESECRFKHL DCPLAELCED SCCFFGHPQG WGSDFSDPNE
CSVDCDQYDC TKSHPVGRTK RCQFGDKCTK FECSFLHSEK RQACESAGDC QDFDCSKLHP
ESREEPCVKG AKCLEFHCQK LHPASRELCD KGKLCTEYAC DKLHEAGRRK KCKWRDRCKL
PFCPWLHPIN RSKQFCDRGD SCDDFDCALV HPPGRCSPCK YGERCWNHIC ECLHPEAWNP
CPNGLGCRDV TCDCSHSPRR PKPCTQGSDC RNRDCAGLHP GMSSVSNAPL QRSSALKSDH
QRRIDREANR LPVLNYREQF LERLQTEKVL IVRAETGSGK TTQLPQYAAE CFGGLVICTQ
PRVMAAVSIA HRVAQEFDGC DVGESVGYKV GGENSAPGSG IMFMTESCLI RYCQSNESLD
NVSVLIVDEA HERSLNVDIV LGLAKLIRIK RPDNFYVVIA SATIDPQLFR DFFNCGVLDI
PGRMYDVSLQ YIPPAFDSNP DVFIKSHLVP SLIKALRDHS DGYALVFLPG EREIQQAIKA
FQQQQTEDNC VALPLYGSLP REEQVKVLDF KPSQDSDRLV VFCTNVAETS LTINGVRLVV
DSGLAKESRF DAKRRITVLE LRQISQSAAN QRKGRAGRTA PGHCVRLYSE DVLKSAEFVP
EILRSSLDLV VLLLIKLKLK PLEFSFLDKP NEEMLIHSYQ TLMDLGCLSG VESLSNAGEL
FAELGLDPRL SAFIVRAHEH FGQLELAVTV ACILTAPGSI FFLGRDKEKK EGLQKRALEA
FSHESDILYE VSVFDSWSNA GKLINGKCKN CGKVARNFQN SCRSCRVGHS NSNRLNNKVM
EHIEKTRTSF LKTIKKSKWF LELQKVESSC EDTIQVVGSC LEQVIPEQVT CLLVKRLPSE
GIKIVDSNIR ARISNTSVFA QRPQDCEYFV AVRVRQMVSG MYIVDGLHPL KDPTTVSDRR
SHPLEKIFTE ANASSNLLKA VNSKIKDESS QISEEQRRWI VLSHNADEAS IDVYARASES
SELRSKLKSL IDKSKLTYLQ EQHMLETKGF RATFQGGLQV KEVHICTLNR TDSEVSSSNN
EGATDSAESD NGLAQLLVSA PCGFEEETIR AHSDSTAKIH HTNQRRRRQE KFKVFISNMP
ANWKESDVQD LIRKSECLNA VVPIRIFPPA QPGIGTSRAL LTLNSETERD SLIKSLSTVL
CNIGPFPISL ISKKNGGTFV KQVSPEIKPC EDKTPSIPEL FFVKFNESKH AVEFYNKIRA
GSIVGCSAEW TESVFISHPD LFPDLNSLIE QSGDPTVKST SVPKPDKTLE IRLSGPQQDK
IKLVANKLRS LFSPITIRHV SNKEKTLFYE IKKTGLFDAW AKELNLVCEF RDD
//
