ID A0A267ERC3_9PLAT Unreviewed; 596 AA.
AC A0A267ERC3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
GN ORFNames=BOX15_Mlig005755g2 {ECO:0000313|EMBL:PAA64093.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA64093.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA64093.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA64093.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA64093.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA64093.1}.
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DR EMBL; NIVC01001783; PAA64093.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267ERC3; -.
DR STRING; 282301.A0A267ERC3; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000215902}.
FT DOMAIN 92..270
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 596 AA; 68310 MW; 4556FCF864F3E83D CRC64;
MLGHFISKVS YQGKVHRIPF KVVRSDRSFA LLGRDILTIE IDFSKADGSE ATRVFRARLE
LIPDAQPKYI KARSIPFAYK DRLKDEIDKL LAEGIIEPVT FSQWASPIVI VPKADGRLRL
CVDYKQTLNP QLMKDSHPIP TLEEAFSTVA GCRMYTILDL KAAYNQVELE EDSKPLTVMS
TPFGNYQYNR LVFGIRTALS IFQRYISQVI QDVDGAIAYV DDILIGGESE KQLKDRESQV
RERLEQHGLK VNEEKCQICQ SRVRFLGFIL DNGMILPDPE KVRALQEMET PKTMAELESL
IGLVRFSGRF VPNLSHYLEP LTRLMRGRRE FQWDSEQDEA FQRIKSMLIE DSALANYDPK
KPVALECDAS QKGLGGVLIQ DNRPVLYISK RLSEAEKKYS QIEREALAIV WSTQRCQRFL
AGCHFKLITD HRPLTYIFGP KEGLPTRVSA RLQRWAISLM AFDYTIEYQR SQLMKSDALS
RLLNNETART YIIGSIQLPS TIISIQEVRD QSQDCPEIVL LKKAIWTSNF NDPRICPYKA
VADELTIESD VVLREMRVIL PKTLRLSAVQ MAHSTHLGID RTKSLLRAQF WWPGLD
//
