ID A0A267ESG2_9PLAT Unreviewed; 1029 AA.
AC A0A267ESG2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:PAA64451.1};
DE Flags: Fragment;
GN ORFNames=BOX15_Mlig031418g1 {ECO:0000313|EMBL:PAA64451.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA64451.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA64451.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA64451.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA64451.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA64451.1}.
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DR EMBL; NIVC01001750; PAA64451.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267ESG2; -.
DR STRING; 282301.A0A267ESG2; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR PANTHER; PTHR13803:SF39; SECRETORY 24AB, ISOFORM A; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR SUPFAM; SSF82919; Zn-finger domain of Sec23/24; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 348..385
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 421..653
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 658..742
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 753..852
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 898..971
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 1..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 867..899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..249
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PAA64451.1"
SQ SEQUENCE 1029 AA; 113056 MW; B77012E059FB0B07 CRC64;
QYPGYRQQRP PQPPQPPQPP QPQPLRPGMQ QNYQQPLPQK PLPPQQQQQQ QGSSLPLPFG
GQATYSHQVK APNLMSSNNS EISLHRLDIS NRPSPVPLAA MEAMEGGGPG GTIAPPMPPQ
QQQQQQQIHP GMPNGSNGAG SHYQSQPAVW PPPSQPAQHQ TQPLRPPMPP PPPSAPSPPS
GAPYGPPRPP MPPQQQPRPP MPPPPGPYQP QSQPQQQRPP MPPQPQAPPT LRPPGPPQPP
APMPPSGIPP TARLDGSLRS SQDGSTQRHV NLLQDRQLLS PTEGIEVLKP SVKHYPGDAN
CDPEVMCCTL NVIPSTSSLL QKARLPLGLL LHPFKDLRNL PVIQASVIVR CRSCRTYINP
FVQLIDQRRW RCNVCYRTND LPDEFQYDPV SKVYGEPSRR PEVRSATVEF IAPQEYTVRP
PPPATYVMLF DVSLGAAYLS TVCQVLLRSL DRLPGDARTQ LAIMTFNGFL HLYQLDGPRP
RMLVLPDLDE AAPPLHDGLL VTVSECRDAI AELLETLPIQ EFPEAPGSCL GTALQMAYKL
AQSYGGRVTA FVASLPSLGP GALQNRDDPS TRAGKPSSGI LQPGTDFYKR LALDCCGVQL
GIDLFCLAPQ PVDLPSLLPA SLFSSGDFFH YPDMAERPDE ERARLSTDFN RYVTRKIGFE
AVMRLRCTKG ISISAFHGSC FVRSTDLLSL PTVNPDAGFG IQLALEDSLA DVQLAVCQAA
LLYTSAKGER RIRVHTLAVP VTSRLEDVFR GADQRAVAGL LALMATDRTI GSSLTDAREA
LVNAVVDLIT AYGNCALSSG QRIGSLCVPY HLRLLPALVL ALMKCTAFRL GVSTRLDERA
GALAAMKLTP LRFLLMRAYP DLYALHPSAW PPPPPQQQQQ QQQEDQKQNN QSVSDDEIDE
PPRLHLSAQF LERGGLYLLD AGRELLLFVF SGMPQAVYQQ LFAVDSFQQI RDGQLGLPEL
DNPLSERVRG FVECLQSDRP FGAPLTLLRE DGRQRGRFTR YLVEDRSEGG ASQSYQEFLQ
TLQKMVKYS
//
