ID A0A267EUE1_9PLAT Unreviewed; 381 AA.
AC A0A267EUE1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Arp2/3 complex 41 kDa subunit {ECO:0000256|ARBA:ARBA00041244};
DE AltName: Full=p41-ARC {ECO:0000256|ARBA:ARBA00041789};
DE Flags: Fragment;
GN ORFNames=BOX15_Mlig032797g2 {ECO:0000313|EMBL:PAA64362.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA64362.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA64362.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA64362.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA64362.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the WD repeat ARPC1 family.
CC {ECO:0000256|ARBA:ARBA00006260}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA64362.1}.
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DR EMBL; NIVC01001758; PAA64362.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267EUE1; -.
DR STRING; 282301.A0A267EUE1; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005885; C:Arp2/3 protein complex; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR017383; ARPC1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10709; ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1; 1.
DR PANTHER; PTHR10709:SF2; ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 1.
DR PIRSF; PIRSF038093; ARP2/3_su1; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 59..90
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 115..187
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PAA64362.1"
SQ SEQUENCE 381 AA; 41931 MW; 1164B2EC537A71A5 CRC64;
TLIFLKRSQT MIEELSFGPV PITCHSFNKD CSQLALSLNS NTVDIYKKSG QKWEKLQSLE
EHSERVTSID WAANTDRIVT ASADRNAHVW TRDSTGQFRP TLVLLRIDRA ATVVKWSPLE
NKFAVGSGAK LVSVCHFEPE HNWWVCKQIK KPFKSTVTCL AWHPNNCLLA VGATDFKARI
VSAYLKEADE KPAATCWGGN MKFSNVMAEY TNGGSGWIRD VAFNGDGSLM AWVSHDSSVS
VANGSTQTLA VLRFAMLPML TCCWLSDTAL VAAGHDCYPV VFRYEAGSAS LSIAGQLNMS
ADQSGGSTKM TAKTMFGNMD RMATEDSVEK LTTVHQNSIN QLAVIVSDAS RVRRFSTVGV
DGRLVVWDTD TIEQKVANLR I
//
