ID   A0A267EY71_9PLAT        Unreviewed;       708 AA.
AC   A0A267EY71;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=IRS-type PTB domain-containing protein {ECO:0000259|SMART:SM00310};
GN   ORFNames=BOX15_Mlig000391g4 {ECO:0000313|EMBL:PAA66461.1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA66461.1, ECO:0000313|Proteomes:UP000215902};
RN   [1] {ECO:0000313|EMBL:PAA66461.1, ECO:0000313|Proteomes:UP000215902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DV1 {ECO:0000313|EMBL:PAA66461.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:PAA66461.1};
RA   Berezikov E.;
RT   "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT   model organism for stem cell research.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAA66461.1}.
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DR   EMBL; NIVC01001557; PAA66461.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A267EY71; -.
DR   STRING; 282301.A0A267EY71; -.
DR   Proteomes; UP000215902; Unassembled WGS sequence.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   InterPro; IPR002404; IRS_PTB.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   Pfam; PF02174; IRS; 1.
DR   SMART; SM01244; IRS; 1.
DR   SMART; SM00310; PTBI; 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000215902}.
FT   DOMAIN          147..254
FT                   /note="IRS-type PTB"
FT                   /evidence="ECO:0000259|SMART:SM00310"
FT   REGION          264..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          318..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          369..519
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          596..621
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          640..691
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        272..287
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        384..404
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        436..454
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        466..485
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        486..500
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        503..519
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        596..620
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        644..658
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   708 AA;  76918 MW;  4E5E8D879E357E29 CRC64;
     MEDTASLKDS SMTIVQAADS TIAFAYIKEV QAKKKRFFVL KSQPRRSSLT NEFESGKSTL
     NLPPRYFLYA YKNKKCYERG EPKRVYDLAN VILLSRSTKK ANQTILGVCL QDEALYLEFD
     TEDELSRWYF HLNEIFSAQR NCLWPELKQC VNVTLKNKEL AAASSKHGKP NLPGQYRFCL
     TDSAVLLVKD DLLNPVLSLP FPCIRSCTHS TVSNLLKIDL GRLSPLGEGL LHFKAEQSSP
     FKELVEHLVR CLYETGSRDL EIVKSRKNRR NSRQTSSTVS GSTADDYQAQ RPASVHCFNQ
     RTACAHCAAR ASVSSAAQMK PSQSSSGLGS DGSCSGSRGL SLPPPDCQSQ CSSAQQQQQQ
     QEDYCLMEMS TGSNDVGGTG GVAFRSRSPN SSMSLSTTSE VTGGGGGADS ERGPSAVSTG
     HRGFGPADEQ LQHHQHHQGS PISRANSIGC RPQSRGGLLS QYPVVHHPHH SQQQQQQQRS
     PHMQSRSRFQ HQHQHHHRNS SSHQVFAEQQ GFSRPRTTSD AASLNASCAN CGTSSSGGLL
     RGFRPRAISY GNKFGRPAAQ PADGEVLGVC DIASSSGASP APSLALSSCM RPLSESTASS
     SGELAVPAAV SQQPSRLSAD DEGSYVTMLL RPTRSCLRQN SYQQQRELDE HKGLNGDDDF
     DPYWTPPGRL DSLLGPGTSV EPPTVDSAAS LVGGSEDYFM MDLGGATD
//