ID A0A267EZ72_9PLAT Unreviewed; 513 AA.
AC A0A267EZ72;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=ANK_REP_REGION domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig005083g1 {ECO:0000313|EMBL:PAA66052.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA66052.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA66052.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA66052.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA66052.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the centaurin gamma-like family.
CC {ECO:0000256|ARBA:ARBA00005430}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA66052.1}.
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DR EMBL; NIVC01001595; PAA66052.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267EZ72; -.
DR STRING; 282301.A0A267EZ72; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01250; PH_AGAP; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45819; CENTAURIN-GAMMA-1A; 1.
DR PANTHER; PTHR45819:SF5; CENTAURIN-GAMMA-1A; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 34..183
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 221..338
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 376..408
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 513 AA; 54561 MW; 6B080EC134DF0922 CRC64;
MQQQQQQQGK FFPLSSSSNA GNRVGPPLGS GRAIPVKQGS LYKKAVNALN REWKKKYVTL
SEDGKLTYHP NLHDYMENSH GKDIDLSRTT VKIPGQLRPT SNGLLKSQQQ QQQQPEDGSK
KRRHRRAKSG NRGGGGGGAD QDVEESDGYE FMIVSLENRT WHFEAASQEE RDEWVRAIEH
SILRSLQGPS AYGNYGTSGG SSNCLAGGGG GGGGSSGSGS IRGVFGNSEC ADCGRPGPDW
ASLNLGALVC IECSGVHRQL GTHLSRIRSL TLDDWPANHL LVMRAIGNKL ANSVWEARLP
CHATFRKPSP ESDREAKEIF IRAKYERREF LPDLPFRDSP VQQQLVDAIA RSDTRQVILC
LAVAGPAVNE PYSKQDPRAA IHIAATLGQL VYLQLLLWHG ADVAIRDAEG RNAHFYATAA
GKPDCAEFLR AAGCPAGVPA SASAAGASAA SSNSPISNPS ATASVASASA AAAASTLPRR
RSKTTPTTAA QPPQPPTASS GNAPTQSTAE IGL
//
