ID A0A267EZ74_9PLAT Unreviewed; 1308 AA.
AC A0A267EZ74;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:PAA66247.1};
DE Flags: Fragment;
GN ORFNames=BOX15_Mlig003284g2 {ECO:0000313|EMBL:PAA66247.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA66247.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA66247.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA66247.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA66247.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA66247.1}.
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DR EMBL; NIVC01001575; PAA66247.1; -; Genomic_DNA.
DR STRING; 282301.A0A267EZ74; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd21759; CBD_MYO6-like; 1.
DR CDD; cd01382; MYSc_Myo6; 1.
DR CDD; cd21958; MyUb_Myo6; 1.
DR CDD; cd22249; UDM1_RNF168_RNF169-like; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 6.10.220.10; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR049016; MYO6_lever.
DR InterPro; IPR032412; Myosin-VI_CBD.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR036114; MYSc_Myo6.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF745; UNCONVENTIONAL MYOSIN-VI; 1.
DR Pfam; PF21521; MYO6_lever; 1.
DR Pfam; PF16521; Myosin-VI_CBD; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902}.
FT DOMAIN 23..74
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 78..808
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 688..710
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 974..1049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1135..1163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 172..179
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PAA66247.1"
SQ SEQUENCE 1308 AA; 147422 MW; FF7A864BA910ADAE CRC64;
LRGFLSRCDL LKNHYLGLSK SAMDGKKVWA PHPKEGYKLG KITDLGSENV VVETLSSPKE
VLTVPYNRLF PSEEYDNKDV EDNCALMYLN EATLLNNIRL RYMKNAIYTY VANILIAVNP
YFEVPKLYAK DTIKAYQGKS LGTMPPHVFA IGDKAYRDMK AFKASQAIIV SGESGSGKTE
TAKHIFKYLT ENYGAHAGPI EQRIVESNPL LEGFGNAKTV RNNNSSRFGK FVEIHFDNRS
LVTGGYISHY LLEKSRICVQ SEGERNYHIF YRLCAGADAA LRQKLGLVAP DQFRYLNQGN
TQYFCTKASE AQIPKEVKSK QYLQIGALKD IQLDDVKDFR NVDKAMTDMG LADSEKQDIY
SVVAGVLHLG NVNFEESGQA QGVVSVTPAS RPSLDKAAQL LGVDPARLEE SLITRITQAA
RGGAQGGIVR IALRLDEAAS ARDALAKAVY SRLFDYIVLR VNQALPFSGS QSYIGVLDIA
GFEYFQRNSY EQFSINYCNE KLQQFFNERV LKEEQQLYQK EGLNVKKIEF VDNQDCIDLI
EAKGSGIFYL LDEQSKLPKP SPETFTLEVY AKNKNHFRLA YPRKSKLKSH RELRDDEGFL
IRHFAGAVCY HTDQFIEKNN DALHASLEAI VKQSSSGLVR SLFDDAAGGV GATVAADGSV
RKAGGGGSKI GTGKLAFISV GSKFKAQLAQ LMDKLRSTGT CFIRCIKPNV RMVDHLFEGA
DILSQLQCSG MASVLDLMQQ GYPSRTKFDE LYQLYKGRLP PQLSRLDPRL FCKLLFHALG
LNENDFKFGI SKVFFRPGKF AEFDQLLRSD PENIAALVAK VKSWLVRYRW RKAQYCTWEV
VKLRRKIAWR REMLVKVQKT MRMWICVKKY RPRIRGLAKV QSLRNRLSSM NDIVGQLKAD
KDAAKKSVDT LIAEVDGVVK QIKSAQRMSY AEIDAIYSKL SAKFDASFAE LKKRLEQQKV
REEQERLRRI QEEMERERAK KADEERQRQQ AEEEKRAKAE LEERRRREEA ERKKQEEADR
KAAAVLQKQM EEEAEANRKQ SQDQEQERLD RELALRLASE DANQVEDLQG AGGGLTRGAN
VLQKRAQMGN SKYDLSKWKY AELRDTINTS CDLELLAACR EEFQRRLKVY HEWKQKNKQR
GAASGAAGAG GAGGKSEGSR APQSVLENAV TVEGAVAAQR QLAGRIGEPG DPKSQRYFRI
PFARPNELNR GTEADQHSGG LWWAHFDGRW IARQMEVQPG QPAVLLVAGV DDMSMCELGL
EETGLPQKKG AEVTATEFDR EWEKHGGAAV LKQHRAAVSS MFLKKNMK
//
