ID A0A267F1S1_9PLAT Unreviewed; 858 AA.
AC A0A267F1S1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Striatin N-terminal domain-containing protein {ECO:0000259|Pfam:PF08232};
GN ORFNames=BOX15_Mlig031478g1 {ECO:0000313|EMBL:PAA67711.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA67711.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA67711.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA67711.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA67711.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the WD repeat striatin family.
CC {ECO:0000256|ARBA:ARBA00009616}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA67711.1}.
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DR EMBL; NIVC01001461; PAA67711.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267F1S1; -.
DR STRING; 282301.A0A267F1S1; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:UniProt.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.20.5.300; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR013258; Striatin_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR15653:SF0; CONNECTOR OF KINASE TO AP-1, ISOFORM E; 1.
DR PANTHER; PTHR15653; STRIATIN; 1.
DR Pfam; PF08232; Striatin; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 42..189
FT /note="Striatin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08232"
FT REPEAT 500..534
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 572..605
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 779..820
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 61..88
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 16..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..303
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..396
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 858 AA; 90406 MW; 97F8B4A557296548 CRC64;
MEDQSAFGVG SVDGYGKQAQ QGQNLGEENP TDGSNTKDPF YTMPGVLHFL QTEWSKFEME
RSQWEVERAE LQARIAFLQG ERKGQENLKH DLVRRIKMLE FALRQERAKF HRLKFGSEPP
GGAAIAAATA GDATDGDSGA SPAVSQLLDP EELLRETSTQ TAATKAKAKD GRQLIRQYLQ
EIGYVDTILD ARQARLQQLI GASGTTASAA APVAAAATVS SASNDSKPPT SQQQQPPPPP
SHQQHQQQQQ PQQMRQITSR SQQQPQQRGR SIQEQLSSLI PGINIAGDDE DDDEDDDADD
ADVDVGVGGS GRLVRGGGKT ALSEEDQAMA TFDFVLDQQD SDIQQPAEDS KDSAAAAVAG
GEDGAGGVDE DAEWNLDERT RSKMEAFKKE RIRGSKKSTG SAGGGSGGGR VGMLDAFLDG
FDRGEEGGTV DDFDGVTPSS AAAAAVAASE EEGFRSAMGL SLGDLQNIDV TNERDYDDDV
GISAGGSASA RRTWASKFNL RSHLDSVRSL AFHPTDSALL TASEDGTMKL WNLSGRAVHQ
EAGSPTSAGS DSQRSAGGTA GPQVELEPVH TYRGHAGPVL TVCVSPDGGL ACTGGLDGCV
RVWRLPPSLS GLDQYDAFDA SLVGEALEGH QDAVWSLAAM GPDTVFSIGA DSTLRAWRTR
HHGNQQGDDE SGSSSPLLRT SELPGRPTSL AIVPADPGKL LVSMATVADS AGSCLLLVDA
ETGQTVLRMP TSSAGEGEGA AASATRVVAH PTQATAMAGY SDRCIRCYDY ASGELTHSMV
AHLDSVTSLA VDPNGLYLVS GSHDASLRVW SLDDPRSCVQ EIAAHRRKFD EAVHDVALHP
AKSLLASAGA DALAKVFV
//
