ID A0A267F1T7_9PLAT Unreviewed; 565 AA.
AC A0A267F1T7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Amiloride-sensitive sodium channel {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig031565g1 {ECO:0000313|EMBL:PAA67184.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA67184.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA67184.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA67184.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA67184.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA67184.1}.
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DR EMBL; NIVC01001503; PAA67184.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267F1T7; -.
DR STRING; 282301.A0A267F1T7; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR InterPro; IPR001873; ENaC.
DR PANTHER; PTHR11690:SF301; AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 61..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 565 AA; 66088 MW; BD7FD8C0DA883440 CRC64;
MATASQAPRT KQEQQQQQQR REQERRNTLR FIINEFNDYG HRTTVHGLGH MYQSTDTCRK
LFWLCITLVS CGACAVHIYF IVANYMETPV NSVILQGRIR QEFPDVTFCN MYPISESVQY
HAAKEIHGHI SNRWKYFSGF IRAGNFSAND KVGRLKVART FMQIFWASED TRDLAHDDDL
FIVQCSYKNR QCSNKQFKMV QNLRYWNCYT FAPKFDGGHE DRQVYSSNED EGLSLILYTN
SHLRNVHPKN GLTTIRDVYY DYEDEILNHL GDQSNFLERY LENYNLSLNQ LLAGDKLEPD
GMRVILHEKD TYPHMDMNSV IVGNGDFSNI NFYMERKLSK NRPEHPCRVE TSGTEDRMEY
MAYYPGSNIR YPGPRPPPNF KKFKRARLDY IVDKSQALFW SACHCYTHIM PFQCFNTELC
YHCRDGTDPA EIERTLRHIW CHDRVYEHRL KHKIFDYFRD SQNFQPCSVN NYNVKMGSSA
WPSQRDIQFL INQYVLPAFQ KETVGARSYN HILKNTSVAP IHDIISQESS TTAAEFLVAR
TSNWTAARGV TVRRGLAESV NSVLL
//
