ID A0A267F3Q2_9PLAT Unreviewed; 1511 AA.
AC A0A267F3Q2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
DE Flags: Fragment;
GN ORFNames=BOX15_Mlig024402g2 {ECO:0000313|EMBL:PAA68353.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA68353.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA68353.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA68353.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA68353.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA68353.1}.
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DR EMBL; NIVC01001402; PAA68353.1; -; Genomic_DNA.
DR STRING; 282301.A0A267F3Q2; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00063; FN3; 2.
DR CDD; cd00064; FU; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF525; INSULIN-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00261; FU; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1511
FT /note="receptor protein-tyrosine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012334209"
FT TRANSMEM 1099..1121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1158..1438
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 738..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PAA68353.1"
SQ SEQUENCE 1511 AA; 169472 MW; 98916D151B21281F CRC64;
ASLMPLLLLL LLPLLGCYGG LGFADGKVCN TVSHAMLSSF KSYNYSHCTV VDGSIVLSMM
EMNGELTFPN VVEISGFVVL YRLKNVTSLG RLFPRLTVIR GFSTHENYAL VIFDLPDLQD
MALPALRYIG RGGVRVENAP KLCYYKSVNW AAIVRPDFIR EVRFDNVPDR VLCSDVCPGR
LQWIDESSKY VYHSECPVAE NCWSRDTCQS LCSPACGDRG CLLGGNSSAC CHQNCLGGCR
GPGNADCIAC RHLLLDGRCV DRCPASHVSH QNWMCISHAD CLSRRYSSKN AIAKSSFRSS
RGTAMKLFNG TCVETCPLGY EISSNHTCVK CVDKANCTRY CEGLLVHSIE DLEAVKGCTS
IGQLIISLSD NIPDLERKLE ENFRNLTEIE EFLLVTNSRD LTSLSFLANL RVVHGKHVVD
DATRAARPTI KIEHTDFLQS LWNTTGGRRV SVPRGKVQFY MNRRLCYNRI QTFVNETLDV
AEKVNELEDL SPKTNGDLAY CINRTFDIVV GLVSASGVIL HWPDLVVSDQ RYVLGYSIYY
RLVGPDETVQ YADPSTCEIR QWQTTFSPCD NVYSLNKPEP DPTGKGPPPK PLPNSCHLQN
CSQCIGDCQN RLGKRQCQKY VHDLRPASRY ALFVMPQILL ERQQEYGSKS RIIYVETLPT
QPSPPHQFDG KAASSDEIRL EWRPPLVPNG RVTHYLLWVK EIQSKQANYA LKDYCEEKRR
GPLDLLVSAK LPLLNKGDSQ LLEPDGRSGS SGGGRSFPAN SSLSCRRHCQ CEQRPDLKRR
EKIIYFEDTL LRIMFRRRPE SDSMRILHRN ATRRFRFGRR NASSLLSFPV GTESRLASPS
ALLDPLLPDP ADATPAPVAT VAPTTAPKTN CPELKCHEDI VEAIAPPQDT RGLADGYTVV
RGTQYTVTNL RHFTSYELML VACLDEFQHP QYSTTLHLCS NPARIMRRTL ALPDADEIPA
RSLSAEPVPA PSGYSTDFQL LWRQPDSPNG AVIYYDVEYK TDSHRSWQYH CVSFQEWLNR
GHRHQVRQPA QRQSLAGAAN GSSSSASMQQ LIGGTLLKSV PEGDYQVRVR AVSLFQPGRW
SLPVPMRVRR RPGRLTADAI AGVLLVAMLL LGALVVIIAW VTYRRINREK TVVNENPDYW
SYTYEPDEWE VPRDQVTYST ADRLGTGSFG RVYRGLVRSL NTPAARYIRQ SEDVPVAVKS
VNDKATMRER HEFLQEATHM KKFRQCAHVV RLIGVVSENV PILVLMELME NGDLKTCLRQ
MRPDTDGPVL PMYSRDQLVL WCAQIADGMY YLETRKYIHR DLAARNCMVT AAFTVKIGDF
GMTRDVYYSD YYKKEGQAPL PVRWMAPESL RDGVFTTASD VWSYGVVLWE IASLASQPFN
GRSNEEVLNM VKSGKTLEPP EDCPEFLADL MARCWAQKPK QRSSFSGLLA CIDEQPELRA
DFRQASWYHS GHAGDSAVTV CLPDRSSAAS SCSSAATLPA CTTSAALKQV EEQIPMLHQQ
SVPNAYVHLR A
//
