ID A0A267F847_9PLAT Unreviewed; 1706 AA.
AC A0A267F847;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=SEC7 domain-containing protein {ECO:0000259|PROSITE:PS50190};
GN ORFNames=BOX15_Mlig000993g1 {ECO:0000313|EMBL:PAA69926.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA69926.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA69926.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA69926.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA69926.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA69926.1}.
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DR EMBL; NIVC01001280; PAA69926.1; -; Genomic_DNA.
DR STRING; 282301.A0A267F847; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032629; DCB_dom.
DR InterPro; IPR015403; Mon2/Sec7/BIG1-like_HDS.
DR InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR InterPro; IPR046455; Sec7/BIG1-like_C.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF375; LD29171P; 1.
DR Pfam; PF20252; BIG2_C; 1.
DR Pfam; PF16213; DCB; 1.
DR Pfam; PF01369; Sec7; 1.
DR Pfam; PF09324; Sec7-like_HDS; 1.
DR Pfam; PF12783; Sec7-like_HUS; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 603..794
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 40..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..598
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1706 AA; 193491 MW; D9A6A7C8E321FD38 CRC64;
MTSASMFLIR ALQKILSEKE IRRSHNSKLR ELCERTLKEL KGREQEDNSP SQNSVLPPLK
SDSNLLENEK YLLPFEHACH SKSAQIVITS LDCLQKLIAY GHIPNKTVAD GSGKKLIEHI
TELITSCFHG PETDEGVQLQ VIKVLLTVMT AQDVEVHEGY VLKIVRTCCN IYLVSKSSIN
QATAKATLTQ MLNDIFSRME NKIIEASTVI EEEADISKEE KPNAPEEGNL GVCDDASAYC
ADDKQATATI IRGILDEIID KTEVSVHNGE PKVSAEDSEK ESISASLPDD DGSAKGNLER
VPSRSESSLP TELKDGVEDI SSLSYSHVSQ KDAFLVFRSL CKLSMKPLPE GHPDPKSHEL
RSKILALELL LSILQNPGPV FKTNETFTNA IKQYLCVALS RNGVSSVQEV FELSCAIFLS
LLSHFKQHLK PQIEVFFKDI FLYILENPSS SFGHKWIIIQ IMTRICSDAQ CVVDLYLNYD
CEMNSANIFE RLVKDLAKAA QGTHAKELGC TPMQEKQMRT KSLECLVSIL KCMMEWSRDL
YHNPHNHSNL NVVEYHKSEL STTITDQKTP GSLDPDSRES SNSLSSLPGA SGNPSVPNES
VDHFEVRKQQ KEMVEAGIGL FNKKPIKGIK YLQENKLLGP TIEDVADFLR SEERLDQAVL
GDFLSDNDDY SRQVMYAYVD QQNFENMDFV SALRKFLESF RLPGEAQKID RLVEKFASRY
FECNQNNTIF SSADAAYVLA YSIIMLTTDL HSSQIKAHNK MSKESYIKMN RGINDTRDLP
EEYLSKIYDE IRGKEIKMKT TSASTRPKPK VTTPVPTSEK QRKIIFHMEM EQMAKAAKEL
MENVSHLPSD FTSATNVELT RPMFKVVWTP FLAAFSVGLQ DTDDHDISTL CLEGIRSAIR
IACIFYMELE RDAYVQALSR FTFLTANSIT EMKAKNIDTI KTLITVANTD GNYLGRSWLE
ILRCISTLEL AQLIGSGVKS QFITGSSVAS HASGSSATLK DNLSSSIDPE AFRDHKKIQL
LQEQIGETSS QSVVVAVDRI FTGSTRLNGE SIVHFVDALC KVSRDELVSN HPRMFSLQKI
VEISYYNMGR IRLQWSRIWE VLGKHFNEAG CNSNEDIAVF AVDSLRQLST KFLEKGELPN
FRFQKDFMKP FEIIMKKNTS KNIRDMVVQC VAQMVNSQYF NIKSGWKNVF SVFFLAASDQ
EEGIVDLAFQ TTIRIITEIM EKQFSSVLDS FQDAVKTLSE FACNVKFPDT SMEAIRYIRV
CARYVAEKGM IFRDHQGDTD VHVQEDDRVW VRGWFPILFE LTCVISRCKL DVRTRSLTVL
FEIMKTYGGQ FTQSWWKELF GVIFRIFDEI KMSDSPAERI EWMNTTCNHA LYAIVDVFTQ
YYDTLCPILL NELYAQLKWC VQQDNEQLAR AGTNCFENFV ISNGTNFGPE IWQVTCNSLK
EIFERTVPSR LLTWSPASPE KSANQQLDEG LSNQALFNSL LIKCVVQFEL IVAFDNIIFY
PAASRKEDQE NWASAQHPME ELPAIAEKLD EDRGMYRHLS TDQLVVLADC LMESHMFAKK
FNLDHEQRNL LWKAGFKGKA KPNLLKQETQ SLSCCLRILF RLNSDPSRVR ESELIHTKLV
NMCSDALQHY LSLPTDIHRE AWNSLLLLVL VRLSRLPSDK LRRHLTVYYQ LLCDCLLVQN
LPPEIKAGLR RVFMRAGALA QLLPAA
//
