ID A0A267F9M1_9PLAT Unreviewed; 815 AA.
AC A0A267F9M1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=LRRCT domain-containing protein {ECO:0000259|SMART:SM00082};
GN ORFNames=BOX15_Mlig010801g1 {ECO:0000313|EMBL:PAA69847.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA69847.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA69847.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA69847.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA69847.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA69847.1}.
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DR EMBL; NIVC01001284; PAA69847.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267F9M1; -.
DR STRING; 282301.A0A267F9M1; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR017241; Toll-like_receptor.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR PANTHER; PTHR24373:SF398; TIR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 5.
DR Pfam; PF01463; LRRCT; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 8.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 5.
DR SMART; SM00365; LRR_SD22; 7.
DR SMART; SM00369; LRR_TYP; 14.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR PROSITE; PS51450; LRR; 4.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..815
FT /note="LRRCT domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012628080"
FT TRANSMEM 730..751
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 669..722
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT REGION 759..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 774..799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 815 AA; 89994 MW; F00E168AA552D344 CRC64;
MPALLQLLVH LLQLYEASSL RLADVIAAGD LGYRCPSRCW CELPHPAVAP STAVLSVTCS
GKGLTEVPCD LLDPATLELN LDDNRLADLP VSIAASAPHL RVLSASKNAI TKLNKNLFTA
LPNLVELRLS HNRLQNLDAK DLSSCVNLRI IDLSHNMLSV LPFDLLDNLP VWFEANLSHN
RLRSVTSQSQ TSAGSSTDAL ERPPVMTARQ LNRDTRLDLS HNLLESVDSR FRWPVASCPA
LLDLSGNPAL SYTGSGALKP LLRSVSADCD LDELRLRRLG LARLPAYAFR GRDLRLHSLR
RLSLASNAIA TVENGALNSL TRLSELDLSD NRLTEIPNLS DLNNLMRLDL SHNLLTIFVD
PTRLPANLRW LSLGRNSLHN LHPSVFTRFA SLQSLDLRDN GLKDFRPTRQ QISGLTELLL
GGNELRREHL AGIFAASPKL LRLDLSRNRI SQIPDNLTGD CPHLRFLNLS WNGFPQIEPL
DLGARELEEL DMTGNRLQIL ADYGSAGLSK LHVGVNNIST IDTQAFLHST NVQLLDLSDN
PMEARTLALF KSSLDRLASS LRVFKLNRYE IFAYLKNNNW GLFREFNELE ELELSRCNIR
QPPGPGVVFP SSLRRLALDY NPIRDIDSDA FRSASHLRDV SIRSARISSV SADAMRSLFG
LRRIDLVGNP LRCDCGRLRH FWRWALATNV SVVGLHSRQL RCASPSALRN RPVLDLQLAS
CESQFSRIPA VIAVAASLFI LLIAAIVYAA LCRGGDESDS AGEDDDGERD VGSSTGSVLV
QQRQQLASPT STTAAASARS RRDRFSATSK CIIEV
//
