ID A0A267FBC0_9PLAT Unreviewed; 667 AA.
AC A0A267FBC0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=SH2 domain-containing protein {ECO:0000259|PROSITE:PS50001};
GN ORFNames=BOX15_Mlig016551g1 {ECO:0000313|EMBL:PAA70993.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA70993.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA70993.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA70993.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA70993.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA70993.1}.
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DR EMBL; NIVC01001190; PAA70993.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267FBC0; -.
DR STRING; 282301.A0A267FBC0; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR45734:SF10; BLISTERY, ISOFORM A; 1.
DR PANTHER; PTHR45734; TENSIN; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 357..475
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 76..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 401..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 667 AA; 73316 MW; F045EAFF60F35FCA CRC64;
MEDKRLFSSA FHASGGTSGS FGRQQHSTNS QWSHQSHPTA ASRVSHLAAG GVSRQQDFGD
PLQDLERLLN RLLNDADVDG EPQTKSKRHP ETFQQSKKHG NIDWKIRQDA IVKDRELRDG
VSMRRKEFVT NRPNNHHRSR RSAVETAATS NYQIEKPGFT EQNLGTAGNY DHWFAGQQIS
TDHTNNPRHS RYRSDFGGDE LKAPEQKMVG RVPPSPSWPF NCEQERQVGR EIEITDLRNQ
RERAPRQSST AAFGSDASVA GGSQRAVSHR REATLRASAE QLDHLSRRDG AASGSSTNVA
AALVPHRRSA SDAAVRGYRP TSEDSLDYEE TPRVVRGRNG EDDGQWANEA EAAMSAWYQP
NISRGQAVAA LRDAPAGSFI VRDSQTYPGA YGLAVRVLRP PAPQQQQRQQ PRSHLTAQDP
RDSLVRHFLI EVSPGGGGVR IRGCSNEPVF RSLSELVQCH SLTPLALPCC LRLPKLTKAQ
TATMATSVRQ SGPKSSLTAV GREPRTGAEE ATSGRRGTTH KVLYFCTVDV PFSAVNNQTQ
WPHKAVSSAV GQVVRPGGPR PIECRMRISG RGIKLSGLGW HTEFRLAYSA EDCLACELDL
AGRRYSDTVG TQTVSSLFGL LVKKYGFYGD QNACLVLGGN LDSSAKSIVE FVNRSCLPSA
SLMQQHR
//
