ID   A0A267FCY9_9PLAT        Unreviewed;       671 AA.
AC   A0A267FCY9;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|Pfam:PF13676};
GN   ORFNames=BOX15_Mlig033212g1 {ECO:0000313|EMBL:PAA71651.1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA71651.1, ECO:0000313|Proteomes:UP000215902};
RN   [1] {ECO:0000313|EMBL:PAA71651.1, ECO:0000313|Proteomes:UP000215902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DV1 {ECO:0000313|EMBL:PAA71651.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:PAA71651.1};
RA   Berezikov E.;
RT   "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT   model organism for stem cell research.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAA71651.1}.
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DR   EMBL; NIVC01001150; PAA71651.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A267FCY9; -.
DR   Proteomes; UP000215902; Unassembled WGS sequence.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   InterPro; IPR001562; Znf_Btk_motif.
DR   PANTHER; PTHR46270; ARMADILLO-TYPE FOLD-RELATED; 1.
DR   PANTHER; PTHR46270:SF2; TIR DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00779; BTK; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS51113; ZF_BTK; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00432};
KW   Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00432};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00432}.
FT   DOMAIN          423..530
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|Pfam:PF13676"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   671 AA;  73384 MW;  D30E7CC81458B428 CRC64;
     MDSASKQEDG SAKQRLPSAS KQEDGSAKQR LAVLVCGHSA SRQWLNAASE KLQAVSDRRI
     ECREATEVAP RSLRARARLV QASGAALVLA EARLQRSPIL MELINFIHAS GLPIAVLLMQ
     SFYEPSGALA AIGTAHDCIL SGAGDPASDW ASRAASHLMS RAKPVRAAAA AGATDDADEK
     QLVGVEAASK AGGSGVFLSY QPDGEKAVAL VQTSLSTAVR CRPDRRNREA IEACRVFVAI
     MSPGYEASAD SLHDLDFARL RRKEVVPVNA VPKAQKWRPS GWLALAVAGR LYHRLSDEAS
     AAEQHYDSTP LKDFVAAVQA GLQDRPTEEE AEAAEVRALT AEAEACKKEL LDLGGTWPPA
     EKSTAMELSQ AFKHLTVEES QPKTQANLPY NLIQYSVTRM SLEPPKPLFD ARGVPIVRSF
     DAMLSYQWAS QDLVRTFREQ LSVYNVDAWM DIWGGMQGNV NDSMARAVES SRMIVCFFTA
     KYQQSANCLL ELKYAVRRDR PLLFLLVEPS TRPLDWVSEL MAKSVVIPFT GMSDAPKLED
     GIPRLVRVIE TVKKVSAHEA LRPRRREDVS EEVYRLERQI SAAKDAVHEL KGTQRFSTCS
     RCSVKYDPTS VGSDSCAKHS AYYIGGNIMA GRWVCCSQTD TKAPGCSKAP HISEPRQWAT
     ITGGAKKWLP E
//