ID   A0A267FD89_9PLAT        Unreviewed;      1512 AA.
AC   A0A267FD89;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=Orc1-like AAA ATPase domain-containing protein {ECO:0000259|Pfam:PF13191};
GN   ORFNames=BOX15_Mlig006751g1 {ECO:0000313|EMBL:PAA71127.1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA71127.1, ECO:0000313|Proteomes:UP000215902};
RN   [1] {ECO:0000313|EMBL:PAA71127.1, ECO:0000313|Proteomes:UP000215902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DV1 {ECO:0000313|EMBL:PAA71127.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:PAA71127.1};
RA   Berezikov E.;
RT   "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT   model organism for stem cell research.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAA71127.1}.
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DR   EMBL; NIVC01001184; PAA71127.1; -; Genomic_DNA.
DR   STRING; 282301.A0A267FD89; -.
DR   Proteomes; UP000215902; Unassembled WGS sequence.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR19871; BETA TRANSDUCIN-RELATED PROTEIN; 1.
DR   PANTHER; PTHR19871:SF42; NACHT DOMAIN- AND WD REPEAT-CONTAINING PROTEIN 1-LIKE ISOFORM X1; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   SUPFAM; SSF69322; Tricorn protease domain 2; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   DOMAIN          166..302
FT                   /note="Orc1-like AAA ATPase"
FT                   /evidence="ECO:0000259|Pfam:PF13191"
FT   REPEAT          727..768
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REGION          1480..1512
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1496..1512
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1512 AA;  171010 MW;  48C652D800E4D4B7 CRC64;
     MPESESTILA LNKTSVLEQE LRQTVLRSRG SHSDTLMFVR TFDNLKDQVG QPLAALYTDI
     EPGRDEVDLE AAHAFVTVKR DLELMVPEDI IHRAQISWIP EGGVNPERSR IHENHVKKIC
     AQIIRVLEPQ IRQIGLDLER HQTEQQSLMH TIQENENYCL QHAAECYGRK TMLAKMKAYL
     NSDSMIPMVV HGPSGSGKTT LMAKCFSKLK DWLPESSTCV VRVVGVSSRS GNVRYLLGSI
     CRELLLKWKE QGDPPQKRFA SNPEEMLDFA GLVNEFTARL QQASRDRPLV ILLDSLGQLT
     EEYQGRRCHW LPKVLPKYVK VIASTVGDER VGVLGQLKSM YSDASPDHFM EMEQLTVEEA
     EKILSSWLAK EGKTLTTPQL EHVLSAFNCV PLPLQLRLSF HESLNWPPSF LPREFAAKTL
     KQSVTFYLSR LESGFGDLLV KRALGYLTAA KNGLTEAELL DILSLDDHVM DVLNFQFHLP
     VRRCPPIAWL RLRNALGEFL TEKSVDNCVT IVWAFNMFNE AAAERYLNQK EKPVLHKALA
     EYFDGMWAGN KRKPHLGNEA GSNRFVSSQP YYFERQEPPG FVCNDRKLAE LPWHLRESQQ
     FESLKQKCLC NFDFILAKML ASSVRHVLDL YESVLSAEPR DKDLRLISNS LYLSRAELEL
     DPKQLASQLL GRITDVLKAD RPKAPADPKK YPFVHALFYR ARRNNVPTLV PSKSCMTTPS
     EIVLDLLQGH RLPITAVCIS EDGTTGFTSS QEDTIKVWDL TNSRVVSTIE GSGSQVLSMT
     LGRQESVLIT SELTCVKVYA VKIGCLLFTI PVQDDPCSVV VNGDTNNLVC FHQGICVMRT
     WNLERLTKVC DKTLTETGLH QDRTVVVSTR CNADLVLYGL RGSNFARVVH CRSGQDVLKL
     SCLDKASLVT AVQTSREYYI VACQATDLHT RVHMFFLELF DTGKGKSVRR IKGCSSDSVV
     DELMLTNIQQ HVISLNPMRD KNMTDIVAWN LETEEHKHFT RHPGISSIGA VYDFRCVITG
     SLAENALRMW NVQQNMQSAP QKTESLVNLA DIVIDAGNNR YALTKLSDNS VIHAWSLSAN
     KFSGKVVKSA KSIAGPNDMV LMDRHFVIVL ARPGFSPKVP NAKFVYQTLT IFDIQKQKFT
     VNLNNVLIVP CAYEEYHVIH GNQLLCINEF HTNFLVYSLE SGEIIRRIKP EFSFDPNKKR
     PSALLEGSVL QRENEMFEEF INSRKQTVFM TPWERRNESK SAKTRRYRSE WEEKKQRADE
     LEQEKGNGIA DFLISKDQST VVSSFFAHHI CVFNLSNGTQ QSVLEHPNAL LHLFTASLSP
     NGRYLAHTIY NEQQEMSQLC LWDCRTGKVK KSFNEGGVGA VAVNSDASIL VYGTDRGELQ
     VRDCRRSPAK VRVAKTSACV NFQQSSHRNF IQLFRDDKWA LIYARSLSVW NMQSLEMLSI
     LTPDQPLHSI RLALNDQLIV FSSKDSNDPI ILKMLSANSK RPQRVGARKF GEADSTDSSE
     DEDMPVERSA DD
//