ID A0A267FFK0_9PLAT Unreviewed; 2844 AA.
AC A0A267FFK0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Fibrillin-2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig025420g1 {ECO:0000313|EMBL:PAA72493.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA72493.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA72493.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA72493.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA72493.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA72493.1}.
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DR EMBL; NIVC01001089; PAA72493.1; -; Genomic_DNA.
DR STRING; 282301.A0A267FFK0; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 19.
DR CDD; cd19941; TIL; 1.
DR Gene3D; 2.10.25.10; Laminin; 46.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR003645; Fol_N.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR24039; FIBRILLIN-RELATED; 1.
DR PANTHER; PTHR24039:SF28; FIBULIN-1; 1.
DR Pfam; PF12662; cEGF; 2.
DR Pfam; PF12947; EGF_3; 11.
DR Pfam; PF07645; EGF_CA; 28.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF01826; TIL; 1.
DR SMART; SM00041; CT; 1.
DR SMART; SM00181; EGF; 54.
DR SMART; SM00179; EGF_CA; 45.
DR SMART; SM00274; FOLN; 7.
DR SMART; SM00280; KAZAL; 2.
DR SMART; SM00209; TSP1; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 7.
DR SUPFAM; SSF57184; Growth factor receptor domain; 14.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF57567; Serine protease inhibitors; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 33.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS01186; EGF_2; 30.
DR PROSITE; PS50026; EGF_3; 41.
DR PROSITE; PS01187; EGF_CA; 15.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50092; TSP1; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 229..273
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 274..316
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 317..356
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 360..402
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 403..438
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 477..520
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 521..558
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 562..603
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 604..646
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 647..687
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 726..766
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 771..810
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 811..850
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 986..1026
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1065..1103
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1106..1146
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1189..1230
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1231..1272
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1273..1313
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1314..1355
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1398..1439
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1440..1480
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1481..1523
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1524..1563
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1655..1697
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1698..1740
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1741..1783
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1784..1825
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1879..1919
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1968..2008
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2009..2051
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2052..2091
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2092..2132
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2133..2177
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2178..2219
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2220..2262
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2265..2311
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2312..2351
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2352..2394
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2395..2436
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2437..2477
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2706..2756
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 2754..2840
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT DISULFID 821..838
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2362..2379
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2844 AA; 305266 MW; 1B5AA68878182B85 CRC64;
MDGDECKPGC SETPDPECVG NAHERAKTTC NRLREIFAPC AAAMAAVKDS FDVYIDSCVY
DTCLGGVDLC QTATTIAAVC QSRYNSSSQW RRADFCPKTC GENQHYESCA SPCQPTCVQP
NVTALMASGL CAGRCTEACV CNEGYVMTSG RCVRPSRCGC QVDGLYYNIG DMMIKPNCTE
RCNCTSPGAT SLTCTSYGCH KYGFCGFEND MYDCHCKKGF HGNGVVCDDD DECALGAATK
TGPCSPHATC RNTVGSFNCT CNSGWRGDGI VCDDIDECEE NKPCNATTEE CFNSPGSFEC
RCQDGFMRNS KTKQCDDKDE CKLNQHSCHR ASTKCRNTYG RYECDCKSGY ERVNRNKCKN
INECANSTLN NCHRSYATCT DTPGSYKCTC HQGFTGNGTV CEDVDECKNK NACYFNATCT
NTIGSFYCTC DDGNRGCTGP DPCLDVKCNG TQVYCYRGVC YCERGFVKNV TTGLCEDESE
CDTGNNNCTK MNALCLNTFG SYDCQCLPGY VYNPVTKVCE DIDECLENRH DCNGNAQCVN
TDGGYQCQCQ DGYMGHCEEC RDIDECEFNL HLCDKEYATC NNTIGSYICT CKAGFIGNGK
VCVDIDECCS GASNCPQLAA CINTPGSFEC RCSAGYVMSR DKSSCEDENE CLSSKNDCSQ
FAKCINNVGS YSCQCLPGYS GDGVNCTKDN TKLDCNGVRC HPQAVCDNAT CVCLGGFEGN
GAQCSDIDEC TRYPGLCDQQ ATCYNTPGSY ACQCKEGLSG DGKICYNDTN LITPCMRPNV
CVNGICTELP QGKYRCDCRS GYELRADTCV DIDECERPET CSSLSNSVCK NTPGSHLCAC
NFGYEERVTG GTRVCASIEQ CARDQYLCGD NAECLDIDGG YVCECKSGYW PVAGSQPTTC
AKGGGKKCLD VNCPDGAYCK SGKCKCLEPT FSATTGPDGE LRCVQVQDAC TGVSCPANST
CQGANGGAGC VCNFGLHFNP AGECVDIREC ENPLLNDCDL QNGRCVDLVG GYRCECSDGF
SLDSATGRCV NSENSCDCGP FGLCLRNNSC WCRSGYTDVG GRCVDIDECS GSRQPCHRLA
DCINTAGSYR CECPANYDGD GYNFCDLNEC KLGSDACASN ARCINTLGSY RCECPDGYIG
DGKICIKGDN PCLFNNGGCG SVALCTWDNQ QVTCQCPAGY SGNGLQCYDI NECMEGTHNC
DRDHAICTNN PGSFYCMCKR GYMGDGVKCR DIDECATGKS NCHPDARCSN TDGAFNCACK
PGYRGDGVAT CDDVGDCRAK SLCDSNARCV YTPQGYTCEC NPGYQGNGYD ACRDINECAQ
GTHQCVEHAE CRNTPGSYAC QCGAGFVGDG RKFCNDINEC LDPKSCSGKQ LTVCVNLHGG
FSCPCAPGAQ LKGGRCEDIN ECDSPALNKC HASATCTNTQ GSYTCACQKG YIGDGINCQD
VDECLSGTAN CDKNALCVNT PGGFDCRCSA GLLGNGTTCD DVDECDKKKP RNQCHKLATC
INKNPGYACV CPPGFDGTGF FCAKRNPCST PGLCSSNATC VFDGTNTRCI CKSGYVGNGR
ICVADNSCTA GTHTCDVATS TCVSRKPIGF DCECKPGFHK EGNLCVDNDE CDPASPYFRP
GVCGDPLMAK CANSPGGFNC LCTALAIKSG IRCIPLDVCK RGGAEAGCST HANCEYLSPG
HRCVCKPGFV GDGKTCTDID ECTDGTDACY GGATCRNTVG GYRCECPKGL VQAADPRTCV
DFDECTNDPY ICGNYSRCVN TRGGYQCECV LGWTWNANTK RCEDVDECKT GTHPCHSLAE
CTNTPGSCTC RCRPGYNGDG VYFCELNQNC PPPKSALCPA GTICRDRGNS TYDCRCPADQ
LDKGVESCAS GVCVHFCQKV DPCWTRAPRC SPFAKCQTVN GEARCVCLDG FTGNGVVCDD
VNECAGPNQC NTSISSCRNL DNRVHRLNYT CDCVSGYENV LGTYRCVNIN ECDRGATCQA
NAKCVDTPGS YQCECNQGFR PVGPRGCVDI DECSENADDC NRGTADCVNL VGSFACRCKL
GLEMLNRTHC QDIDECASPG VCGPEQTCHN TFASYACSCP VGFTVNGVYC VDVDECSRNG
SCHPTALCNN TRGGYQCYCP RGQQMSLTGA CEHINQCSER ADACPAGALC VDNTTTGYAC
ACPEGYINPP DNERLCQDID ECSMGLHNCT GAGQLCVNTM GSFRCKCQAG FALKGTDCVD
VDECKLAAEA NLGFCQPGGS CVNTPGSFVC NCPDGYEFKD TACANIDECA LPSAARLAAR
CPPNQVCVDT VGSYRCYCPK GYILDSDNNC VDIDECKSAN ACPNGVCTNT AGNYTCTCSA
GYQPSGPFLC VDIDECAKPD ACGDPDYGVC TNQPGSFSCT CKPGSAMVDN SLCQRIDECV
LANVTCPPNS HCVSTSSGHR CQCNAGYVAN EYGQCLNEDE CGRGTHKCDP MAQCVDTIGS
YTCSCRHGYQ GDGRTCNSVC EEACAPNQMC RVTEQNTPEC TCDCVGKRCL VQGQVCDNKG
RTHASEKAMY EFACRAKEAD ITVSYFTPCK NKCNKIECPE SHICVTDPDL NKPICKCRPC
TDADRNSGPV CTMDLVQFNN RCDYIKYKCY WKDSVSLSNM TVCRQPITCK VSEWSQWGGC
SRTCGLGFQV RTRTMLREAQ FNGNCPYELT AYADCYSGPC PDGPCRSKIC PNSHICVEVN
GTAVCRCPDC DGRGDSAVCG VVGNKTDTYK NLCELERSAC EKNSTYLVYH RGACGQVPPK
VPTHCSLVYN FQRYKFPDGC ESQDLLPMHR CDGGCGNSTD TCCVPLHTRT MTARYRCPDK
SMVIRALDVN VSCSCQKKSR YVTG
//
