ID A0A267FGX4_9PLAT Unreviewed; 912 AA.
AC A0A267FGX4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=ANK_REP_REGION domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig027582g1 {ECO:0000313|EMBL:PAA72319.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA72319.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA72319.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA72319.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA72319.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the centaurin gamma-like family.
CC {ECO:0000256|ARBA:ARBA00005430}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA72319.1}.
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DR EMBL; NIVC01001098; PAA72319.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267FGX4; -.
DR STRING; 282301.A0A267FGX4; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08204; ArfGap; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR45819; CENTAURIN-GAMMA-1A; 1.
DR PANTHER; PTHR45819:SF5; CENTAURIN-GAMMA-1A; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 568..682
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 699..819
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REGION 290..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 403..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 912 AA; 97767 MW; 7D7FBCC6FEFAE9AB CRC64;
MTASGKDSDS FELLESAIKE EIQRFESVHP CIYAIYDLIE TISNRELKDA IHNNLVTIED
AFVNSQEWTL NRNVKELKLG LLGSADSGKS ALVHRFLTGS FLQDASPEGG RFKCRVGLSG
APHLALIRDE AEPPSPQFAV WCDACLLVFA AGRPGSLVAA ADLRRRLADV RRPPDLPLIV
VGVLDSASES RAQAEAVSRR QAAAAAELGL RQEDMVYFEA SVATGYNVER VFTEACQAAL
AARRNRGLAE LPAAGDATPV AFAARRETPQ PPAPPARFPQ PAPELDFARS TEKVAHSRNG
SAVSLQQQQQ SAAAPRVSRD SRFPTVTSAV AHWLMLGSML AWAGGVSKYL HKYQASPRYV
SKLLTTQPKT PICIGIMTAL EPTPIPKPIC MENNKTHCVQ SAEPAASVKL RPKPAVPQRL
SRQRPSSQLL QTPPSAAAAV SGDVTEPHVT LRPKRPSTRR ASSVAAESRK NLTATRPQQQ
QAATLAANPL PVEVEIRTRN AVNQAAQDRR QPAAPAAPPP QIPLRDKRSS QLHPESAAPQ
SQPQRRSHLF GSSPDAAPAV SVGPGRAIPV KQGVLAKRCT GGISSEWRRK FVTLGEDGRL
TYYASLHEYM ENGRGRCVDL GQATVRLQEH PHHHHKRGKS GGSGSEAAGF ELVTLDGRVR
QFEAPNRDVR DAWVTALRAA TLGRLRAGRD GDVDGNDAAA LLDAARRLPG NERCADCGAP
QPDWASVSLG LLICLRCSGA HRQLGTHLSR VRSLHLDSWT TGHALPLSVV GNALGNGVWE
ARLPPGARPS PGADSAEWEA FARAKYERGD FLPEAARPSD LADAAASGDT RRLLAALARA
SPADLDAVPA DPSRLPPLHA CAAAGSRAHL QLLLWRGASP GARDRRGRTA SDCARAAGHA
DCEKLLRLAC SS
//
