ID A0A267FIW5_9PLAT Unreviewed; 787 AA.
AC A0A267FIW5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Lig_chan-Glu_bd domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig020788g3 {ECO:0000313|EMBL:PAA73745.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA73745.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA73745.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA73745.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA73745.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA73745.1}.
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DR EMBL; NIVC01000995; PAA73745.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267FIW5; -.
DR STRING; 282301.A0A267FIW5; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0050906; P:detection of stimulus involved in sensory perception; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966:SF422; KAINATE-TYPE IONOTROPIC GLUTAMATE RECEPTOR SUBUNIT 1D; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..787
FT /note="Lig_chan-Glu_bd domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012447511"
FT TRANSMEM 480..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 547..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 736..758
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 351..713
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 361..424
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 768..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 787 AA; 85324 MW; A5B3D650895197C0 CRC64;
MGLCVTPLLL AIAAGLSAGE ELRIGLLLPS RASASGSYSN GVVQQIEAFN RSSDGTSVQI
LGLTLAMDYA LPEVMQSWQP HFIISFLSCP LPPATVASAG SVEIVLDAAD CLDAAAVAGT
GSAIILQSAA LPAAAVELTR NFSSIAVGLG ASVTGASAKL LSRLSSAWQQ NRQLSLVPLD
EGGNSTSALL SADAALLLER NRTRLAEIMQ QSCNASIVLA YPVLLNDTGN DCPYCQLSPA
NLTDPFAHYG SRPGLCQLLD RLSSVVRPSE LLQTSSVLKT ISDTVRTAGG SVGVAAAMQI
IRDSLVERQF VQCRSSRSGT LGYHGWFGLG SGLDLTRALA TQRRSLLEGR HLIIGLKMVA
PFSFAGSVTP EGFEVNVTGL AIDMLDEIAR RLKFTYSLRQ PADGLWGGVY PNGTWNGMVK
EILDMKIDFA IGPFTMTAIR QTVIDFSEAF MEDGNTILIK KPGQENPMFR VLSPFSLNSW
LAILGSVFTA AVCMFLFSYL SPFSAWNMNL SEKISDEVSI RENFWSIVGS LLQQGQDFYP
VASSSRFVLG FWWIVTVVMM AYYTADMIGY LTLNIPAATV KNLEELAGQT VIRPVVKSGT
NVQTLFQTSA PGSTYSKIYS LMTDMPFITE TYQGVDLVAN GTQQYAYISD STQLRYIALT
NCDLLLLSDI FNVATFGWPM RKSAVYKADI NREIRSMIDS GLIARWIQKW WRAENICSQD
SSLSDSKPIG IEESSGGFII AAGFYACGLV VLLMEYVADA LTRWCKQQPN RPRGHTAASY
RTTKDHY
//
