ID A0A267FKG2_9PLAT Unreviewed; 1034 AA.
AC A0A267FKG2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Sorting nexin-13 {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig016795g1 {ECO:0000313|EMBL:PAA73694.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA73694.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA73694.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA73694.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA73694.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA73694.1}.
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DR EMBL; NIVC01000997; PAA73694.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267FKG2; -.
DR STRING; 282301.A0A267FKG2; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF3; SORTING NEXIN-13; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 48..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 140..318
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 441..583
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 638..762
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1034 AA; 114739 MW; 306DF5458E210201 CRC64;
MTQVDQQIQR QESEETTHTT AASSLTSSSS SSSNAAASVV GQLSPMAWLA TVVVAAICLL
GPGLLFTGAV CLICFGAGCL LRLAQVGSML GSAFGVDHSS GECRQSRGIG RVIHWYRQEH
LNYRQQAIEQ EQQRRSISGH ARIDALLNEI LDHVMRDYVA DWYDGVSDDK LPPTEMRKLL
HQLMTNIAAR CASAAWTDYL TQQVPEEFGC HIRLYRRSLE QSLRPDDLEA TFFRLECDME
DRRDSRGCLT EGPGQEGFLR DLADTVLCLL LPTQEFQASP SRSLLTDIAV NYLLQPTIEL
FASPDYVNQN IIWFSREDAY AYEFLMQAVL TAEVDGEVKA LLEFVNSEMS RLRSQDAATG
GGGLPTNQPT KADYQTDGQS GRDELNGIKQ QLSSLDYIRT KCEERIRVLQ PAANHLDLVT
QTIQPSTLTK QKSASNLHQL PFDSVMKNSL ALNYFYEFLV TINAVRYLDF FLNIEGFRLS
AASIMFNLFG RTQQQTGSAG RDAASLRASI SEQAASIFAM YFDSAGGGGS GGGGGAGGAD
RLPLLNPGVI RRTQQSIQSG RVDETVFDDL RAEVLRVLEL DQFYGRFKQS QGYRSLLEEM
DLLREDTVSR NSCEGEIDSP LADQEAEDAA SPMEEYEVQY SAKIMRHELI KADGDKHTSY
VIHVCKVCDS SHTYEWDVYR RYSEFDELRS ALVEACEPLG HLHFPAKNSF RNNMNPNLIS
QRQAELDLFL QQALTFNYSA SERYLCARSM LYKFLAPGSL SPGAFASGPG GFGVSGAFGG
AAGGATLPAP LRMMRQGSQD IIDGVKRNLL LRVARPAAGA AAFAQSASTL GQLPEELRAI
GSDLGGSGEV ADQENVPLRI LLLVMDEIFD VRERNKLIRK GIAAVLSKLV RALLGDRVNR
RIVQFARVLT SADRVAYYLQ SFRDSFWPQG QPAAPYPTRD SATLMRTRLL CRAKLLGSVS
TELRQVLGNQ TTRQGVARLF NMFQHANLNR RLVYVLLEGT VCLLFPDYRM DQAFRRMYAR
QRLRIGKPQQ PGSA
//
