ID A0A267FL28_9PLAT Unreviewed; 757 AA.
AC A0A267FL28;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
GN ORFNames=BOX15_Mlig013074g2 {ECO:0000313|EMBL:PAA73749.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA73749.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA73749.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA73749.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA73749.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA73749.1}.
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DR EMBL; NIVC01000995; PAA73749.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267FL28; -.
DR STRING; 282301.A0A267FL28; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0032502; P:developmental process; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011651; Notch_ligand_N.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF07657; MNNL; 1.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 6.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 551..577
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 199..243
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 309..350
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 352..408
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 410..448
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 450..486
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 488..524
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 201..210
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 214..226
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 234..243
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 340..349
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 398..407
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 419..436
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 438..447
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 476..485
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 514..523
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 757 AA; 81571 MW; A0D2905857D68682 CRC64;
MKAGHKQQLQ LQQPLQLLTA RSPLVLLCLL VVVQSGKASR GLEFQLSLRG FSNPAGRLAD
GGCCSASGAC PGACRTFVRV CVTVRHETGA IVGGGGGGFP GPNDSCAIVD NVTDLIGVNN
MSKPLRELRI DPKAWTPDRA FTMVLDLLHL PQPHSLTNKT WGLLIARRVM REKNYLPTGN
WTVHRRTLDG IGLEFGYRFR CRLGFYGNSC QKQCRSRDDM LGHYSCSATG EIQCLPGYSG
ARCTTPICQP ACVHGTCTGP NQCSCFNGWR GSNCSDCIPM PQCSGRGYCT KPLECLCPPG
YGGLFCDIDL RWCQHNENPC LNGGRCRNLD QRGYNYTCEC PPGFTGFHCE REIHDCGQPW
GACLNGGVCR QNGSSADADP STPAGGGELV GGLRSCSCPL GFYGSRCQFN YTTCADRPCG
DRGDCRNLPD GGGFSCSCHP GWAGRGCEEN VNDCPKDYCA NGGQCVDLVN RFQCICRLNY
RGPRCTVNLR DCRNLTCLNG GVCRDLADGL GCDCPAGLSG KFCELGTPAA SDWPPTVSWS
STEDLRRQPG VAVLLLVIAV LLILLLLLAA IVSVFVWQRR RKRRSHQAGV TAAAAAAAAV
AIQDAGSDDD DDGPRRQKID SFGGEESAKL RISCDDFYSI GDVDQPGLAM NNSRCNVLRP
GLAESKMDYF AHKQINNLLS ASQGCLSPRE LRQSAALMHG MRPGQSRPRL QPSSSMQFSG
RLATVSRAGL SSSFVQSASV AMRHTRIPSC DFGHGWA
//