ID A0A267FLG3_9PLAT Unreviewed; 585 AA.
AC A0A267FLG3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Amiloride-sensitive sodium channel {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig012217g2 {ECO:0000313|EMBL:PAA73879.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA73879.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA73879.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA73879.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA73879.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA73879.1}.
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DR EMBL; NIVC01000989; PAA73879.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267FLG3; -.
DR STRING; 282301.A0A267FLG3; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 38..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 546..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 585 AA; 65530 MW; 5FB4FD59672EFD1B CRC64;
MRDRAARANK PQTVGDEFLR FLTFSSVRGV PRLLRARSLG WSVIWAVSVL GFLTVSFYFT
IRLVMQFSTY QTVYEIKNEF NSQKAPFPSV TICNLQPFSA TLLDRIFAST SPLDNVTADM
YNDAFLRLQA SSEDFRSLTW KSFFLRNWGR KASEKTGLKF YEFVLNNTCN FTYSSNSKLR
SMRCDPTRDV QELFSSRYLT CFMLSPPQNI SNSTFSVEMD MYLDTESSLF NRSHLGDESK
AALFTLEDSI GAFVMVHTAR TYPEGYHGVH VLPGTKSVIE ITSVNKEVKL EHFAKDPCTR
KLDQDILALY QEIRPFAYKS TICRRLMIQR MIARSCNCTD PNHPVPEELA SQGFCGEVSQ
DAFSSVESVR NAALNATIKK LVCGLKIELS SDPTSSHGET QCPQPCEEIS YRTTAYQSLW
PPKSNEIDFY RYHIKGNSHL ASKFKVYAEA SALIDSGRLS EATALLDNLG TDLIRENFLR
LHVFRPDIML TISEEKLQIT LEALISQIGG AFSLWAGLTI ITTVELIELL YYVAKRVVVS
LSGARPATQS DDGAEAAPRK QSEPGGSSDL ISGGGGIASQ TFSKL
//
