ID A0A267FMX7_9PLAT Unreviewed; 1156 AA.
AC A0A267FMX7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=BK channel {ECO:0000256|ARBA:ARBA00029579};
DE Flags: Fragment;
GN ORFNames=BOX15_Mlig030539g3 {ECO:0000313|EMBL:PAA75131.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA75131.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA75131.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA75131.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA75131.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA75131.1}.
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DR EMBL; NIVC01000901; PAA75131.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267FMX7; -.
DR STRING; 282301.A0A267FMX7; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR048735; Slowpoke-like_C.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF33; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF21014; Slowpoke_C; 1.
DR PRINTS; PR01449; BKCHANNELA.
DR PRINTS; PR00169; KCHANNEL.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 73..97
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 199..414
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 569..657
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT DOMAIN 1032..1150
FT /note="Ca2+-activated K+ channel Slowpoke-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21014"
FT REGION 109..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PAA75131.1"
SQ SEQUENCE 1156 AA; 128278 MW; A2A36BB8F47C3FBF CRC64;
GLNSKNPREI RIATERATGH ALLELQPKSF LPTGADMVAT IAAFNDTSNV ATRSAPVLPT
APGSVQACTE RRWHYHLAST ALAFLGGLLF LVLYRVVNRL IKLFQRRQRG RPGTGGNHHH
QYEVHEQQKS LRSGSASSGG ALIAPGAAAT SSQQQQQQQD GVAIAPNATR TGSSVASGSS
AIRDWASDLI SAQSVSGRIL AVLVFVLSIS SAGIYIIEAN QLIGSTENCT PWSRNPLSQA
DLAFNTVFLL FFCIRFLAAQ DKFWFWLELY SVVDYCTVPP AFVSLCLSQS WLGLRFMRSL
RVMTLPDVLQ SVSAVKSGAI IRSLQMITIF LSVWLIGAGV THLFENTGDP QSDYSNPNPI
SFGDCLYFTI VTMSTVGFGD ISPKTSWGKF FISIYIMFAL GIFASFIPEI AEIITSRSPY
AGSYKKEHGR KHVIVCGAVT FDSIESFLSD FLHEDRQETD VEVVCINKKE PNLEFQGLLK
RNFGRVVYFT GTVLSPADCQ RVDLESASAV IVLGNKHTED PDAEDASNIM RVISIKNASP
TTRCIIQLLQ YHNKGYLLNI PNWDWRFGDE CVCLAELKQG FLAQSCLAPG FSTLMANLFS
TRAMCKSVRA NTWEKDYQIG SAMEIYSEYF SDSFVGMPFQ DAVEVSFNKL GILLFAMEDK
SDDGDRFLSI NPSGRDTVIY HGCHGFFIAD SQEGVRRAYL YCRKCHSDVT EPKQIKACSC
TRAEDSAGAP GVDSGHCCGE THELTRLRGN SANVRRPEIQ VVSNKALATL KEAEFGSEDN
FGEFVEPRKE SVEYFDLTGM FHWCPDKNFE DVMLTPNSVA RLDLRQHYVV IVFADSDSPL
IGLRSFVMPL RASNFRLNEL RPIVFIGNLD FLQREWGSLK NFPKIYMFPG SPMNRVILRS
AKINLCDMCV ILSAKSRWKD QVDPYLMDKE VVLCTLNIKA MSFAEGLDTS VQAQLQAFQS
KDAKSKSLLA KVAVPILTEI FVGKNIQFLD QEDDDADEEE IYNSQPYACG NAFTAGVLDS
LMSTVFHNMN AMTLIRTLVT GGATPEMEVL MAEGLNLDGT EETPEIQANR HRCRAMQLSM
LDPRLRPHEQ GTFGDLFTGV FKSHGILPLG VYRYRDSYST VELQTTKRVV ITNPGSGFRL
LNSDMLFCLV PFQQSS
//
