ID A0A267FNS6_9PLAT Unreviewed; 498 AA.
AC A0A267FNS6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 13-SEP-2023, entry version 12.
DE RecName: Full=fumarate hydratase {ECO:0000256|ARBA:ARBA00012921};
DE EC=4.2.1.2 {ECO:0000256|ARBA:ARBA00012921};
DE Flags: Fragment;
GN ORFNames=BOX15_Mlig006789g1 {ECO:0000313|EMBL:PAA75458.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA75458.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA75458.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA75458.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA75458.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate
CC from fumarate: step 1/1. {ECO:0000256|ARBA:ARBA00004859}.
CC -!- SIMILARITY: Belongs to the class-II fumarase/aspartase family. Fumarase
CC subfamily. {ECO:0000256|ARBA:ARBA00009084}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA75458.1}.
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DR EMBL; NIVC01000882; PAA75458.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267FNS6; -.
DR STRING; 282301.A0A267FNS6; -.
DR UniPathway; UPA00223; UER01007.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0045239; C:tricarboxylic acid cycle enzyme complex; IEA:InterPro.
DR GO; GO:0004333; F:fumarate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006106; P:fumarate metabolic process; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR CDD; cd01362; Fumarase_classII; 1.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR HAMAP; MF_00743; FumaraseC; 1.
DR InterPro; IPR005677; Fum_hydII.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR018951; Fumarase_C_C.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR NCBIfam; TIGR00979; fumC_II; 1.
DR PANTHER; PTHR11444; ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE; 1.
DR PANTHER; PTHR11444:SF1; FUMARATE HYDRATASE, MITOCHONDRIAL; 1.
DR Pfam; PF10415; FumaraseC_C; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00145; ARGSUCLYASE.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000215902}.
FT DOMAIN 46..377
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 443..495
FT /note="Fumarase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF10415"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PAA75458.1"
SQ SEQUENCE 498 AA; 52732 MW; B0520B00A1A325A7 CRC64;
GFALARHSSK LLLQQLLSGR QVNPVIASMS VRAGAADTRI ERDTFGEIAV PSWAYYGAQT
ARSLINFNIG RDADRMPSQV IRGLAYVKKA AATVNGQHGL DPAVQSAICS AADEVISGQL
DRHFPLVVWQ TGSGTQTNMN MNEVLSNRAI ELLGGQIGSK TPVHPNDHVN MGQSSNDVFP
TAMHVSVAME AAGRLLPSLK RLRDALAAKA DEFQGVVKLG RTHLQDATPL TVGQEFGAFV
HQLDCDLRRI DASLVDVHQL AIGGTAVGTG LNSWPGFGED VAAALARLTG LPFRSAPNKF
EALASHDALV ELSGSLNTTA CSLTKLANDF RLLGSGPRCG LGELTLPENE PGSSIMPGKV
NPTQCEALSM VACQVMGNHV AVTIGGSQGH LQLNVYKPLI VRNVLHSMTL LADASVSFAD
RCVSGTQVNA DRVAELMSQS LMLVTALNPH IGYDKAAAIA KHAHANGLSL RQAALDLGLL
SGDDFDRWVR PENMLGPA
//