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Database: UniProt
Entry: A0A267FNS6_9PLAT
LinkDB: A0A267FNS6_9PLAT
Original site: A0A267FNS6_9PLAT 
ID   A0A267FNS6_9PLAT        Unreviewed;       498 AA.
AC   A0A267FNS6;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   13-SEP-2023, entry version 12.
DE   RecName: Full=fumarate hydratase {ECO:0000256|ARBA:ARBA00012921};
DE            EC=4.2.1.2 {ECO:0000256|ARBA:ARBA00012921};
DE   Flags: Fragment;
GN   ORFNames=BOX15_Mlig006789g1 {ECO:0000313|EMBL:PAA75458.1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA75458.1, ECO:0000313|Proteomes:UP000215902};
RN   [1] {ECO:0000313|EMBL:PAA75458.1, ECO:0000313|Proteomes:UP000215902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DV1 {ECO:0000313|EMBL:PAA75458.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:PAA75458.1};
RA   Berezikov E.;
RT   "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT   model organism for stem cell research.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate
CC       from fumarate: step 1/1. {ECO:0000256|ARBA:ARBA00004859}.
CC   -!- SIMILARITY: Belongs to the class-II fumarase/aspartase family. Fumarase
CC       subfamily. {ECO:0000256|ARBA:ARBA00009084}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAA75458.1}.
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DR   EMBL; NIVC01000882; PAA75458.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A267FNS6; -.
DR   STRING; 282301.A0A267FNS6; -.
DR   UniPathway; UPA00223; UER01007.
DR   Proteomes; UP000215902; Unassembled WGS sequence.
DR   GO; GO:0045239; C:tricarboxylic acid cycle enzyme complex; IEA:InterPro.
DR   GO; GO:0004333; F:fumarate hydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006106; P:fumarate metabolic process; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   CDD; cd01362; Fumarase_classII; 1.
DR   Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR   Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR   Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR   HAMAP; MF_00743; FumaraseC; 1.
DR   InterPro; IPR005677; Fum_hydII.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR018951; Fumarase_C_C.
DR   InterPro; IPR020557; Fumarate_lyase_CS.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   NCBIfam; TIGR00979; fumC_II; 1.
DR   PANTHER; PTHR11444; ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE; 1.
DR   PANTHER; PTHR11444:SF1; FUMARATE HYDRATASE, MITOCHONDRIAL; 1.
DR   Pfam; PF10415; FumaraseC_C; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00145; ARGSUCLYASE.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; L-aspartase-like; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000215902}.
FT   DOMAIN          46..377
FT                   /note="Fumarate lyase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00206"
FT   DOMAIN          443..495
FT                   /note="Fumarase C C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF10415"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:PAA75458.1"
SQ   SEQUENCE   498 AA;  52732 MW;  B0520B00A1A325A7 CRC64;
     GFALARHSSK LLLQQLLSGR QVNPVIASMS VRAGAADTRI ERDTFGEIAV PSWAYYGAQT
     ARSLINFNIG RDADRMPSQV IRGLAYVKKA AATVNGQHGL DPAVQSAICS AADEVISGQL
     DRHFPLVVWQ TGSGTQTNMN MNEVLSNRAI ELLGGQIGSK TPVHPNDHVN MGQSSNDVFP
     TAMHVSVAME AAGRLLPSLK RLRDALAAKA DEFQGVVKLG RTHLQDATPL TVGQEFGAFV
     HQLDCDLRRI DASLVDVHQL AIGGTAVGTG LNSWPGFGED VAAALARLTG LPFRSAPNKF
     EALASHDALV ELSGSLNTTA CSLTKLANDF RLLGSGPRCG LGELTLPENE PGSSIMPGKV
     NPTQCEALSM VACQVMGNHV AVTIGGSQGH LQLNVYKPLI VRNVLHSMTL LADASVSFAD
     RCVSGTQVNA DRVAELMSQS LMLVTALNPH IGYDKAAAIA KHAHANGLSL RQAALDLGLL
     SGDDFDRWVR PENMLGPA
//
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