ID A0A267FP95_9PLAT Unreviewed; 3999 AA.
AC A0A267FP95;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
GN ORFNames=BOX15_Mlig017125g2 {ECO:0000313|EMBL:PAA75596.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA75596.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA75596.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA75596.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA75596.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA75596.1}.
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DR EMBL; NIVC01000873; PAA75596.1; -; Genomic_DNA.
DR STRING; 282301.A0A267FP95; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 30.
DR Gene3D; 2.60.40.60; Cadherins; 29.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF445; CADHERIN-87A; 1.
DR Pfam; PF00028; Cadherin; 13.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 30.
DR SUPFAM; SSF49313; Cadherin-like; 28.
DR PROSITE; PS00232; CADHERIN_1; 1.
DR PROSITE; PS50268; CADHERIN_2; 30.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..3999
FT /note="Cadherin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013238480"
FT TRANSMEM 3874..3898
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 51..155
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 156..261
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 279..367
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 500..573
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 576..674
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 675..778
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 779..885
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1146..1262
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1257..1360
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1363..1465
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1466..1559
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1569..1671
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1672..1779
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1781..1880
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1881..1993
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1988..2097
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2098..2205
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2206..2312
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2313..2414
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2523..2625
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2627..2734
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2738..2838
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2839..2945
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2946..3048
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3050..3160
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3161..3262
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3263..3376
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3377..3498
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3494..3624
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3635..3754
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 3999 AA; 433182 MW; 4ACE5332AE4B4515 CRC64;
MVKANLLSLL SSTMTITVTA TDNGTPTPQS ASVTAQLSII RDVSAPVVDL NATKTFVNVS
EKTTVGTTIG GVFAFDPDRN GTAGGLTYEL IGTPPSNIFF DVNSTNGAIT LKSSLMGDTT
VNYTVVVRVK EASSGKYTDQ AIVISVDRNP GWPVFYPGSR SMNVLVNARV GSLLLTAFAN
DTDSGDTIRY SIKEAGLTSY FYVNPVTGGL FLIGNLTGLS AQVNLTLVAT DNGTIPKATE
SVVSFTIVRS AGSIVFNPPT IVATLNSYNY TSLTLPASIG ISVNATMNDS VGQLRYRLIG
VYPANAFFEI DQVTGEIRLI RQLDRVSTLN LPGLSLQVTA YNTLFPEVLG FGFVNFTISH
NKDKPVIYDT DTSRTVSIEL SLGSVLFSVN ASDPSGDTIR FNMTDPSGRL YLDPVTGVIY
LKQPLAGSSG SIEATVTACD TNSVQLCSSP ITYTVTIDNS TSIPRFTNLP NSINMTAFRS
VGDVLYTAVA TLNLKTSVSI RYSVSGIVPA PSFFQVNAVT GEITLNRSLE LDSNLQYNLV
LNAYDNDLSP SIRGSSTGTL TILVIRNSNP PMISGNLTTG SVTIDQAQPV GVSFFKVNAS
DADGDKLIFS LLSWSNLFYI DPVNGEVSLR QSVLTRSELN YSLNVSVSDG RFPAQIVYFE
LNVSVTRDLS PPTSAQANYT ARITENAAIG SVVVFLNVTD ADLRGSLVYN IRGLYPAETF
FAVNSSGYVT VRDLLYKDVD RRGSYWIIIG VYDSLRPDRV TTLTVSVEVE RNFTGPVVLQ
NVYNRQICTS LPTGSVVLAG ADLNISRVSG TVLTFSISSA DSSFSSNFSL NPSTGDITVL
GSLKAWDGLS SAVISVKDQY GRTEQGLGLV RVTISSYNIT TPPRVVLPTD QILSNVANPL
DGLWDSVPVN TTAFSVTIYN DQLNGTSDAV RNSLMSSYSA SILGSTLAAS FFKIVKRPTL
DCGTGPGCPY QSFDIQVARS LTEDRSLEAW ANFTIAFLFN CDINQSPALT TAFSLRILRN
NDSASYNPST VSISVSAVLE IGTRLPISVS IVDTTKPPFQ PPYYCDIVSV PGGASAATIK
TFIYLDPATC RDFYAIKPLN TWSGGNSINF SISLNENWPS GISIARPYAL NVTLTFASST
WPAEFSPSVL SVNITDTTPV GTGIARLNLT DRDRMGDLMY SLQALSTGAG VFFGIRNVSS
TNISVEVELY IINFLRKDVL EQYQVSLTGY DSAYPKDMTV ANVTINVRRN VGYPSVLSAP
YSRTIGPKWI IGTAVVTVSA TDTVDNDTVT YSLNGSATDN QFFFVQPYTG QIVLKESLQL
TTISTFSLSI VATDSGVPRR EVSTIVTINI LRNESVTPVF GIVPAQYSIN VSENAAVNTS
VLFVNATSQK SPELIRYVAL GDGLATDYFQ VNNMTADITV KSALTAETIT RMILRVQAFS
LADLAETNTA TVTISVIRNE FPPVFLSSEF NVTVGETTEI GTNIYNMSAT DRDAGGVITY
TLQPNTTNDE FFFINAKTGA VYLKTSLMKT SMGLFSLIIS ATDSGVVPRT TTVRLNVLVP
RDAFVLVFNT TSVAVSINYT QTVGAVFYKA VPFDINSTSS YEFRISNADN FFFGINSTTG
EVYVAKSLLL DTLSLTQYQI NISCFETLHP QNVAMMVLTV NVNRNLYGPQ FNQSLYGFSI
LELSAIGTTL GPVRATDMDV GFGKLEVIRH SIQNDSGNPA LSYFYINEVT GMLFLERSMD
GITEDFFNFT VLATDSGPSP QTASTVVSIA IVKQPRPVVD LTQNFFVNIS ENQPVGSSVY
QIRFNNTPSG ITYEATGMGS APYFFSTNAT GAVIVNRNLK EELVTNYNLT LSLYYATSPS
RRTTVNIVIN VRRNENAPVF LSTFYLFRVR PSLPIGSRVG NVSATDADSP RLSYQLSGSA
DCQSHFYVNS ENGDIILKEV LNGSLMADYY FNCTISASDN TLPSPKTTTI SAFLVLQVDT
KPVWSKPNGA PIYLTVSETI SVGSIINLPA IYPLFANDSD MLGSMSYSVI GNYPVNLFFS
YNQTLSAVTL IRSLLTDTQN TASYTLILEA YDSMYRTSAS QITIVLNVSR NANKPTFEYP
AYVVNVLEGV PLGTVLNVAT PAGVVIKATD GDNETITYSL SSSVPSDLDY FYLQPENARL
LVKSKLQDTA KSLFQFTLTA TDSRGGQGFS NLTIAVTRNL SRPIYPESFI NITVSENMPI
GAIVYDLNAT AAVLPDEIRY RLEGDSLVMR LFQVDNITGV LSLSQTLSGS TFTEIDVRVV
AYSRISVTVG TELSSLALLR ITILRNQNAP VFNPKMYTAT VYDGVAVNAL VVTLVATDAD
NDSLTYSMSG GAEALKYFYV VRTTGQIRVA DTIPRFDNQT YEFNVTVSDN RIQEKTDVAT
VRITASKDAS LPFFLQPTNG TTFELRIQVD QAPLVAITKV VADRLNRSQP MVYTTTGVYP
ANMLFQINVT GEIYLAKSLL LDNLKISVYT LLVETYDPIS PRAIGRLNIT IIVDLNPYAP
VFTQRVFTGT VNEFANPGTQ VLQLNATDRI ATDVLAYSLA SSVDTEIQRL FYVNSETGAI
TVRSSLRPNI TAQNYTFQVQ VSDGGKSDSA FATIIVSRNL YYPVFNTLPI NVSNVDETFS
VGYIIYNNIN VTDADNAGAI SLELTGIDTA TEYFSLQMSS GIGAIRIAKS LLLDSSDTFQ
YKLRIVAVEA GAPHMPTTAT ITVNVNRNIN SPVFYGTTSG IYSATVNQYD PIGTFLVRVM
ASDSDLPNNP RSQVTYSIGN STDFYINPST GVITTAAKLT QETYVLQVVA SDSYLPRRQS
TVIVVAITVN TNRHTPSFRV PIYRVNVSES FPIGMSILQL NATDSDGSSS PFGRVVYGLL
GASKDLRYFQ VAYSTGVISL KDTLLGAGLA EVRLTAIASD QGEPPRVGNA TVIIFVTKDV
NATRFNQTEL RVTYNEDLAV GSSVVNLTAI DPDATGRIRY LIVGDGLSSS LFTIGEFTGM
INLSQSFTID SGILYTIRVV AYDEADPIQK ATALVYVTVV RNRNSPSFVG SLPFSVSITE
SQVLGITILQ INATDPDPGP SGELRYSIVD PASLPTDASS WFYVNPLTGA LSVSRTLSLD
GRSLNQYNVS IRVSDQGNLP RSVTGLVMIN VARNLNKPRF LNSTITVTIN ESISVGTTIT
RVVAVDPDPT DNVTYSVVGV PAVYYFDVNS NTGDIFVKYS PGFGTEVLYN LAIVASDGRD
PPGTARTEVI IKVIRNANGP VFSSPTYNFT ISEYTALSTV IGTISATDGD PPNIPSGTLT
YTISLVRSTT GVASLFLLGS RSAALTVASP LWSVPSRPSP TVYTIGIDVT DGSPSPKSNA
TTVFVTVLRN QFSPVFSTKS VNITVNDLSK LGTFIAQLTA TDADSALQPD TNNSRITYFV
DPTNSAANAY FYVNPNTGKV TLSQMLVNNP ANPDSYVFTV YASDSGVPAL NDTASIRVNV
DKTASTGTRT LGFVQPEYTV ELTENAVIGT NVLTLDVIYQ DTDKTVNCNF ASGNEGGYFD
IVGRNGNKDC QMVTKKVIDR EAISRFDLRI SVSHSVSVPG RRRRAVSDAM EPLLSRKRRQ
TYTSYPTVKV LIMVSDTNDN APLFKYPVYP NRTSTQNKYF AAVDMFAPAN TRAITVNATD
ADLGRNAEVS YAPNAWTTAT PPNPPFLLSD ADGSVRTAAT FNRNSTIKYR FGVIAQDNGL
PVRLSSSTEL IVNLIQDKNR MILVVPGPNK EPKVTIPSLE TIRRTLQTAT GQVVLIERVN
PRQYLEGSTI RDDPTGTDIW FVCVNPVTYD ICVRDDAEPT NAFMTNEAKE KIRNMLNGVV
PMETIRAPFG VTTGQLAFKK TSDILYQYGF ASDVWAALIA IAAFIILMCI IVIVYCLVRR
PRDPRFLAAR ANPYDIYAAS QIGSHVGPVS LAASEINGHG GAKIDDIEEQ CLEYNIESVP
AQEQITPQEQ PEYVQIREPN TSSFINPRFQ GMSELVSYH
//
