ID A0A267FRK0_9PLAT Unreviewed; 372 AA.
AC A0A267FRK0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Endophilin-A {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig008239g3 {ECO:0000313|EMBL:PAA76411.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA76411.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA76411.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA76411.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA76411.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the endophilin family.
CC {ECO:0000256|ARBA:ARBA00006697}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA76411.1}.
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DR EMBL; NIVC01000825; PAA76411.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267FRK0; -.
DR STRING; 282301.A0A267FRK0; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd07592; BAR_Endophilin_A; 1.
DR CDD; cd11803; SH3_Endophilin_A; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR035824; Endophilin_A_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14167:SF30; ENDOPHILIN-A; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 18..251
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 311..370
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 245..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 372 AA; 41949 MW; 474FF3047B875CEA CRC64;
MSLAGFKKQL NKANQLFNEK IAGARGTELD PDFMEMERKI DVAGRMVEDL IARTQEYLQP
NPMARARMTA VKGFNNLQNK NKSMVYPQPE GILGESMVKH GKDLGSDSVL GNALVDGGEA
YKQMAEIKYS LEDNVKQNFL DPFTSLQHRE IKEINHHRKK LEGRRLDFDC KKRKAGGSKN
PEEELHMAEE KFVESKNLAE NAMINFLNSD AEHIAALYEF VSSEVVYHQE AVRILSDLQQ
RLEEKRREAA ERPKTEYVPT KRTGAGNNSS LSRDHLPSPQ QQHSANSWRS DNQENHHQQG
ATTPLKSAGG GSTPSCRALY SFSAENSTEL PFEEGDTIAL LAQVDENWYE GEAHGRRGYF
PVNYVEVLVP LP
//
