ID A0A267FWW2_9PLAT Unreviewed; 365 AA.
AC A0A267FWW2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=RRM domain-containing protein {ECO:0000259|PROSITE:PS50102};
DE Flags: Fragment;
GN ORFNames=BOX15_Mlig013926g3 {ECO:0000313|EMBL:PAA78271.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA78271.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA78271.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA78271.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA78271.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the RRM IMP/VICKZ family.
CC {ECO:0000256|ARBA:ARBA00009094}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA78271.1}.
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DR EMBL; NIVC01000696; PAA78271.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267FWW2; -.
DR STRING; 282301.A0A267FWW2; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd22401; KH-I_IGF2BP_rpt2; 1.
DR CDD; cd00590; RRM_SF; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR10288:SF337; IGF-II MRNA-BINDING PROTEIN, ISOFORM L; 1.
DR PANTHER; PTHR10288; KH DOMAIN CONTAINING RNA BINDING PROTEIN; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00322; KH; 2.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50084; KH_TYPE_1; 2.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 40..113
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PAA78271.1"
SQ SEQUENCE 365 AA; 39604 MW; F3E89CFA0588169A CRC64;
IVGAARIAGM SNEKETSAAA ANGGQSSPQS GGSANVKKSH RIRVTGASGK QEDKDLEAMF
AKFGKVLKIE PHNYQDGILV VSMETVDVAN KAVAEVNGAE FQGSKLTLNN DSANQRRQNG
NNVPSQRRSG PPVQAPQLNN PMQVRDFYPV RILVNSDLIG AIIGKGGETI KEITNRSKAR
IDIKREVVTK NIPPRKVQNS QIVFISGTPE ACSAACKEIL TICVNEAKEK TKEDAELNIL
AEDRFCGRII GKDGKNLNTI REKTKTSVQL SNSPTITSFD SMGKSFSMDR IITVRGSLDG
MCQAEAFIAE KLRQCHQLEM PPPPQYPNYP PIGAGGYGNV APGWPYVSFP AMDPRRKYKT
VKAMS
//
