ID   A0A267FZX6_9PLAT        Unreviewed;       324 AA.
AC   A0A267FZX6;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=Endonuclease/exonuclease/phosphatase domain-containing protein {ECO:0000259|Pfam:PF03372};
DE   Flags: Fragment;
GN   ORFNames=BOX15_Mlig014531g3 {ECO:0000313|EMBL:PAA79395.1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA79395.1, ECO:0000313|Proteomes:UP000215902};
RN   [1] {ECO:0000313|EMBL:PAA79395.1, ECO:0000313|Proteomes:UP000215902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DV1 {ECO:0000313|EMBL:PAA79395.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:PAA79395.1};
RA   Berezikov E.;
RT   "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT   model organism for stem cell research.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SUBCELLULAR LOCATION: Nucleus, PML body
CC       {ECO:0000256|ARBA:ARBA00004322}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAA79395.1}.
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DR   EMBL; NIVC01000636; PAA79395.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A267FZX6; -.
DR   STRING; 282301.A0A267FZX6; -.
DR   Proteomes; UP000215902; Unassembled WGS sequence.
DR   GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd09080; TDP2; 1.
DR   Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR009060; UBA-like_sf.
DR   PANTHER; PTHR15822; TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN; 1.
DR   PANTHER; PTHR15822:SF4; TYROSYL-DNA PHOSPHODIESTERASE 2; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   Pfam; PF14555; UBA_4; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   SUPFAM; SSF46934; UBA-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000215902}.
FT   DOMAIN          81..313
FT                   /note="Endonuclease/exonuclease/phosphatase"
FT                   /evidence="ECO:0000259|Pfam:PF03372"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:PAA79395.1"
SQ   SEQUENCE   324 AA;  36002 MW;  5F3F157EEA4415B2 CRC64;
     EVDSPDEDSG DIPPEPVCRR LCDQFAEITG TDSAFALMML QNNGWSLPAA LDRCFGGDAP
     ATLALPAAAS SNEDPRQLCV MSWNLDGLTD QQVEARTRAA IAVLRDAEPH AVHLQEVAPD
     TLDLLRRLLR DRYEFVDGRA HPDDRYFTAT LLRRGRLQLL SPSLHRFEGS RMDRTLLAVR
     VKSANGPEVL LLNTHLESTK DFAAERKRQL STALRTLTES AKPALLAGDL NLRDAELQAI
     GGLPAGVLDA WSHCGARPEA QYTWDATRNR NIQNMGRARC RFDRMLAWRM QPLDFQLVGL
     QPAAGTQLFP SDHWGLVGLF QLQD
//