ID A0A267G3D9_9PLAT Unreviewed; 1154 AA.
AC A0A267G3D9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE Flags: Fragment;
GN ORFNames=BOX15_Mlig022361g1 {ECO:0000313|EMBL:PAA79867.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA79867.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA79867.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA79867.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA79867.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA79867.1}.
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DR EMBL; NIVC01000612; PAA79867.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267G3D9; -.
DR STRING; 282301.A0A267G3D9; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd18044; DEXXQc_SMUBP2; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 2.40.30.270; -; 1.
DR Gene3D; 6.10.250.1010; -; 2.
DR Gene3D; 4.10.1110.10; AN1-like Zinc finger; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR035896; AN1-like_Znf.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR048761; SMUBP-2_HCS1_1B.
DR InterPro; IPR000058; Znf_AN1.
DR PANTHER; PTHR43788:SF19; DNA-BINDING PROTEIN SMUBP-2; 1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF21138; SMUBP-2_HCS1_1B; 1.
DR SMART; SM00154; ZnF_AN1; 1.
DR SUPFAM; SSF118310; AN1-like Zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 1044..1084
FT /note="AN1-type"
FT /evidence="ECO:0000259|SMART:SM00154"
FT REGION 178..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1000..1023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1090..1154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..904
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1008..1023
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1109..1129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PAA79867.1"
SQ SEQUENCE 1154 AA; 124034 MW; 96B80C0F8F474D7C CRC64;
QIKTMEQLEE FVQRQLELVS LERQKEMAAE QDLLKSSARA LQDKGLALHK IYLASQATGM
YGRRVLEFET YQRAKDLPSH SIAPGDIVGI FHSQQEQQQI GSGIVTKVLA RAVCVAMETD
QASSAASSGD GQLEVGYKYS VVKLGSDVTF KRLKKGLLAL LQKPPSLADL LLGERSLAPT
RDLPPPSGES TAASGSSRGV SYFNPHLDES QRAAVELGLR RSDLVMIHGP PGTGKTTTVV
ELVRQLVARG ERLLCCAPSN TAVDNLAERL IASGVRCVRL GHPARQLPQV VEHSLDALLA
RSEDRRIIAD VRADIDKLLS GGRNRRIGAE LRNLRSELRQ REANCVKAIL TRAQAVLCTL
TVGGLNDDST LKEIQFDATV IDECSQATEA ACWLALPRAP KCILAGDPYQ LPPTVRSERA
VAAGFAVTLM ERLLPRSAEA TQLLTVQYRM HRDIMLWSSE AFYSNQLIAH QSVAGHRLAD
LPGFAAVSDG VENDDEFPPL LLVDTAGCDL AELESDDSEM SKANTGEAAI VAEHVSALVT
SGLALSDIAV ISPYNLQVEH IRLALQQQQQ QQSTPSSNLQ SVEVRSVDGF QGREKEAVII
SLVRSNRKGI VGFLSEHRRL NVAVTRARRH LCVIGDCDTV GRGDSVLAGF VQYLLTNAKV
RSASEFAHVL DDIVMASPSQ PSAGGQSQKQ QQKRGNNKKQ QKLDKEAKEA RIEQLINVIR
LLANYSLDNL SSAAAAVGVA FVPTEDGGEL RFLGLNPYER ARLHEECERI GGLQHRSVDD
DAANSAGEGG GRVLLVSKVS GATADKMATE SDKTAAESDK TATESDKMAT ESDKTAAESD
KTATESDKMA TESDKTATES DKMATESDKT ASESDKMATE SDKTASESDK MATESDKMAT
ESDKMATESD QMSAAGNAKV DPLSSGPVAN DATDCPVCGK PVPPGNAELH RVACDRAMRN
RQLRAAVDGA SAAVESAGAV GGKKGSQKKT GVVLGVASNQ KSDGSAIKKQ QANKKKQQAE
AVDNNTEEDF DALLAEFAAM DSVCGYPDCK TPVRTVGHGC AHCRRRYCFS HFVPEVHGCG
QAAREAARRV ASGSATSGPV APPKSNREAV RRAQLHRRLE ARLDDMEQSR RPASAASAAE
SQPKTGNKKK NKKK
//
