ID A0A267G3Q5_9PLAT Unreviewed; 554 AA.
AC A0A267G3Q5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Amiloride-sensitive sodium channel {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig003120g3 {ECO:0000313|EMBL:PAA80670.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA80670.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA80670.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA80670.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA80670.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA80670.1}.
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DR EMBL; NIVC01000571; PAA80670.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267G3Q5; -.
DR STRING; 282301.A0A267G3Q5; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR InterPro; IPR001873; ENaC.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR PANTHER; PTHR11690:SF295; DEGENERIN LIKE; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 66..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 554 AA; 63882 MW; F4F7F73227C3868D CRC64;
MATNSSEKRQ SAGNSRPNKL SKMVEKMRRD GFGESPSKKL LKQFCESTSA HGFHKIFQGS
SILHRIVWLL IIITAFSGFS AHLISLFSRF NEGPVNTEIS VYSTNFVFPD ISICATSHFS
LRRYERNPKI RSLNKPIKEL VSDIRSFWDP NNESDSEING DLLNSLKSYL HEVNITKQSQ
EMILHCDFAG TICSYINFTE YIDPNYFSCF TFSPRERHLL VGGERDGGLS VIMYVGDMMN
FISEEDSLRY SKGFRAVIHE KGTRPEMLEG FYVQEHACTY VQLGYTEEVV LRKCAEEESL
QPLEFVDRYG KVTQYRYSVR DCQVNLYQNF LNESCRCVSE ILPLPAKFRN ITRHNITFCH
HINEERLKQS RGAKSNDSSS VREKQECHDN AINEIHKQVS AKKTKKDSYC PLKCNNTRYE
MRVMQNKWPN DANETRQALW EATQRTMHEA RSRGDSTEVL EEIMEHLKND PYALQRFAKL
TVYSHSTMGN IVRENWAYLA RNLASDIGGI LGLWLGVSII STFEFFELFI QLFSVRRKEN
QQLQAASAAD AELA
//
