ID A0A267G4B4_9PLAT Unreviewed; 811 AA.
AC A0A267G4B4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
DE Flags: Fragment;
GN ORFNames=BOX15_Mlig017290g2 {ECO:0000313|EMBL:PAA80082.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA80082.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA80082.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA80082.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA80082.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA80082.1}.
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DR EMBL; NIVC01000598; PAA80082.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267G4B4; -.
DR STRING; 282301.A0A267G4B4; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR043537; Tiam1/Tiam2/Sif.
DR PANTHER; PTHR46001:SF2; PROTEIN STILL LIFE, ISOFORM SIF TYPE 1; 1.
DR PANTHER; PTHR46001; TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000215902}.
FT DOMAIN 100..293
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 770..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..612
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..797
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PAA80082.1"
SQ SEQUENCE 811 AA; 89314 MW; BD32976DF5459151 CRC64;
PPPPPPPLQA HQSSNRPSSH IVRKVEPSNI RQQQPQQQQL LQKPQQQRAE GSSRLQQLQR
QQPIAASSSP ETSHYRHSNS SESSQTSSQS SQSKLPVAER LRRGIFELLE TERTYVGHLR
NLLDTYILPM SQTVFPRHSE VEQLVETTQQ ILGFQAVFLQ SLDDAVRMEP DLTRFTDAGQ
FRRILFVLSG SFLYHAEHFK LYSSFCAYHS KCQKLLNLEE NPTLREFLLS KNPHQEQSSS
IDSFLIKPIQ RILKYPLLLQ NLCSQAAPGS EEQKQLLEAL RGMETVAEHI NEMQKIYEEY
GPTFEELTRI FKEIHPNKRP VDLSIGDLQM YGTVEWLNAS DNLGKIKKNI DLYTTCFVFK
SAVVMLCRER SRSKRKNSKP SLQSQLSGGP GISELVRFQT VIPVAEVEVR SGFTSETDGV
HLWELVHMRS DAERRSEKVY QLSNCSSEAR NDFLKTIRQM IRDCVRQMSL PSLRQSAPTQ
QQQHQQLPRP RPTPPMRTTS QLSGGQQQQQ PQRHSGHFNL PCHQQQQNQQ QSQPTSAGAT
EQVLQELSEQ QQQLKARSRT CSDLQQAGSS DSSKELSILP PPPPLLTQQQ QPPFDGQRTP
TPPPPPPPPQ QRHLQDELMM ASPELPPSEY DNCGAPTPPI GGGGGGGVGA AIAAGSSSTI
STLNSGGAGG GGRSPSARLL FASGTPLRSP ALSATSSSGG GGCDGGPGLS AAHGADINGA
SPIWKPRSSR GGDGGSGGSG SAADQTMSAS IAYGDYTGLQ AGTRALPGPH VAICQEQQQQ
QQQQQQQQQQ PQHQTPREGR PFFTEEGVTQ L
//
