ID A0A267G524_9PLAT Unreviewed; 976 AA.
AC A0A267G524;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=STAS domain-containing protein {ECO:0000259|PROSITE:PS50801};
GN ORFNames=BOX15_Mlig021751g2 {ECO:0000313|EMBL:PAA81123.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA81123.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA81123.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA81123.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA81123.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA81123.1}.
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DR EMBL; NIVC01000548; PAA81123.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267G524; -.
DR STRING; 282301.A0A267G524; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0098661; P:inorganic anion transmembrane transport; IEA:UniProtKB-UniRule.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF257; ANION TRANSPORTER SULP-7D; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 161..179
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 268..294
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 381..400
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 433..457
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 469..489
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 509..542
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 563..595
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 619..817
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 833..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 931..976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 833..847
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 877..895
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 896..911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 976 AA; 106238 MW; 300DAC707FC75F4E CRC64;
MSGPSAPSNG GDGLGPPSSN GGGGGSVSRR SRKIPTDLRL QLNDAGIRND AEATAGGKIA
SRPAFTEVQL EETFQNKMEP EEQKAHVQNL MDERKAGKEI KDKRAIALGI AAKVFPCLKV
LLNYDIREYG PYDLLSGISV GLFIIPQAIA YSLLANMRPQ AGFYSAFFAM TIYFIFGTSN
HVNMTSQGAV SLLVGEAVRA GIEQVYPNGA GLCAAPNSTT MDINFTTLAG DALTTVAGIT
TATTAYGDSN TTAFDTCISR DDANDRVALS VTMIAGALQL LLGFMQFGFL SIYLSDPING
AFACGAALHI VSSQLRNILG APIPTISGNG KFFLYFIEAI KETLDSKVNV PTLVIFVFFF
LILLVVKIIN ERCIRYIRMP IPIDILVLIV SLLMSKFLFW ETTLNVAPVG DIQKGFEPPK
APLQEHFTTG SGIILNGIVL GIISYSMSVS VAKTFALRNG YEIDPNQEMI AYGAVNFGMC
WFGTFVSASS IACTSLHESL KGKTQVYSLY AISITLIGIL VFAPEFSPVP KCVLSAIIIV
NLKNMILQVE QLPRLWRTNR YDFTIFLVTL AGILGLDLPI GLLIGVVFSL ATVIFRTQAP
KAYLLGRLPN TDIYRNIKKH KKAEQIPGLK IFKFDGSLYF ASAENYRNRL YRQVAMNPKR
VLAKAKTRAK REGRGHGEVD LRTDMLQAEG VRRILEVVAE EGSHSVAEAR LGAQLALPVH
EKHAHFESVA YHSENEETAS TVNVFCIILD MSACAFTDAV GIRLLSQIVD DFSKIGVEIY
LSGCTWLVRS QLRKASFYDK RSEEGFFVTV HDAVIHALSS FYNELLQDEA KLHEEEDEHH
HELHPEDGSA AASTGEGASA EAAPSSGHLH GSKTKQSAAE LARDRRRRIR NESWRRNSNA
DMQSGPTSMR SLQQVMSLPT LAESGVTTPM GAHQPIMGKS GKPAPKFGLP EDSGNLDGID
SQPGLDNAGF ESETKF
//
