ID A0A267G6H2_9PLAT Unreviewed; 823 AA.
AC A0A267G6H2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
DE Flags: Fragment;
GN ORFNames=BOX15_Mlig006170g4 {ECO:0000313|EMBL:PAA81630.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA81630.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA81630.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA81630.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA81630.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|RuleBase:RU363044}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA81630.1}.
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DR EMBL; NIVC01000521; PAA81630.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267G6H2; -.
DR STRING; 282301.A0A267G6H2; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR010285; DNA_helicase_pif1-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049163; Pif1-like_2B_dom.
DR PANTHER; PTHR47642; ATP-DEPENDENT DNA HELICASE; 1.
DR PANTHER; PTHR47642:SF2; ATP-DEPENDENT DNA HELICASE; 1.
DR Pfam; PF05970; PIF1; 1.
DR Pfam; PF21530; Pif1_2B_dom; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU363044};
KW DNA damage {ECO:0000256|RuleBase:RU363044};
KW DNA recombination {ECO:0000256|RuleBase:RU363044};
KW DNA repair {ECO:0000256|RuleBase:RU363044};
KW Helicase {ECO:0000256|RuleBase:RU363044};
KW Hydrolase {ECO:0000256|RuleBase:RU363044};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU363044};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902}.
FT DOMAIN 630..660
FT /note="DNA helicase Pif1-like 2B"
FT /evidence="ECO:0000259|Pfam:PF21530"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PAA81630.1"
SQ SEQUENCE 823 AA; 91821 MW; 9E44EB3A40C11717 CRC64;
RTNTARRIVQ QHLMMQVGAR DYSAQEAMHL VLQTPMYKAS REFVYVQTGE TRAIESRGVC
KNSIEKYANR PAQLENETMY RFFSDYIPPM RQQRRGGEQV AVYKKRLAGK EAVLIVSPFL
RSTESDDKRR EQYYRQQVLL WSCWRTEEQA KGSHASWREA YEAMMQTEAC QLVVRDLDDL
RNDEADEEER EAVADLPDMT AANAESVAGP AYPERQQEDW MAALGAKHAD IQLNVNKNPE
DTLPVAPEGF DWSAASDWQF PSLAEAKQFL MTELTKPVRR VAGITTEDGA GANRQTIDVS
LLNERQRKLY DMIDNQLKLE RLAESDTTNN STESGKMPPP LRVILYGSAG TGKSFLIAAL
RKLIGEDKCK VMAPTGVAAF NIAGETLHSA LKLNVKFSTT ACTTNADGST TSGSSKALSD
MQSVWSNVRY IIIDEFSMVG QRTLAKVHNR LCELFPEEKR DTLEEGYFGG RSIILVGDVF
QLPPVQDKQL YVFNKNAKDN LTPIGYQVYQ SFKTVVYLNK QVRQANDTEF ASILESLREG
KVTEAIWKTV MDKCQVAAAD MLPLDVDGKC TLLYHTNEDV SNANCEELRK IVDDNNPVRI
INATCTGRQP LTGNNATDSS KQKSETGLAR RLFLAIGARV MLTRNLSVQN GLVNGSVGTV
RGICYANGKK PPNDLPDCVW VEFERYNGPA MQAMRLTRGD GSSSSSSSEC ASSVSVVPIL
PVSSQWLQRG ASLSRHQFPL RLAWAITIHK SQGLTIDKAF VQLGKGRKSP PAGLYYTAVS
RVRALSDLFV TCCDFVRFQR LFSTGGILAQ VNEQKRLLAL CEK
//