ID A0A267G6T6_9PLAT Unreviewed; 509 AA.
AC A0A267G6T6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=WD_REPEATS_REGION domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig002737g1 {ECO:0000313|EMBL:PAA89418.1},
GN BOX15_Mlig010491g1 {ECO:0000313|EMBL:PAA81741.1}, BOX15_Mlig033359g1
GN {ECO:0000313|EMBL:PAA51895.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA81741.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA81741.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA81741.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA81741.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat EBI family.
CC {ECO:0000256|ARBA:ARBA00025741}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA81741.1}.
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DR EMBL; NIVC01003338; PAA51895.1; -; Genomic_DNA.
DR EMBL; NIVC01000514; PAA81741.1; -; Genomic_DNA.
DR EMBL; NIVC01000151; PAA89418.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267G6T6; -.
DR STRING; 282301.A0A267G6T6; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.20.960.30; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045183; Ebi-like.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22846:SF2; F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI; 1.
DR PANTHER; PTHR22846; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF08513; LisH; 1.
DR Pfam; PF00400; WD40; 8.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00667; LisH; 1.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50896; LISH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 5.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 157..189
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 222..246
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 256..297
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 339..380
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 381..431
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 432..473
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 509 AA; 55350 MW; 62F56B49E3920794 CRC64;
MSFSSDEVNF LIYRYLQESG YLHSAFLFGV ESHISSTNIN GSMVPPAALL QIIQKGLQYT
EAEISIGEGG SERVVESLSL IDSVMPEVVE MRKKQVAEAE KCRVSGRPGA ASAGSKPFGQ
AVNGEDHMAQ DGDGLASAGR DSLAVPLEIP PSRVTVLRGH ESEVFICAWN PRQNLLASGS
GDSTARLWDA TDLASAVDPK KQLVLKHCIS RGGMDVPSNK DVTSLDWNYD GSRLATGSYD
GFARLWATDG TLVCTLGQHK GPIFALKWNK AGNLILSAGV DKTTIIWDAT TGQAKQQFAF
HTAPALDVDW QSNNTFASCS TDQSIQVCRL GREQPIEIFK GHTNEVNAIK WDPQGRLLAS
CSDDMTLKLW SMDRPHPIHD FKAHQKEIYT IKWSPTGYNS QNPNANLYLA SASFDSTVRL
WDVEAGACAQ VFSNHNEPVY SVAFSPCGHY LASGSFDKCV HIWDIASGSL VHKYQGTGGI
FEVCWNHTGD RVGASAADGT VVILDLRRC
//
