ID A0A267G7S8_9PLAT Unreviewed; 1200 AA.
AC A0A267G7S8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=C2 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig006616g2 {ECO:0000313|EMBL:PAA81477.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA81477.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA81477.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA81477.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA81477.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA81477.1}.
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DR EMBL; NIVC01000527; PAA81477.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267G7S8; -.
DR STRING; 282301.A0A267G7S8; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProt.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:InterPro.
DR CDD; cd04028; C2B_RIM1alpha; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR039032; Rim-like.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12157:SF21; RAB3 INTERACTING MOLECULE, ISOFORM F; 1.
DR PANTHER; PTHR12157; REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF17820; PDZ_6; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000215902}.
FT DOMAIN 460..551
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 616..737
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1046..1164
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 737..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 805..878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 901..960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..328
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..763
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 820..837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 853..878
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 901..920
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..960
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1200 AA; 129254 MW; AE8697CED47BA159 CRC64;
MSLLARSLHK ASPSEAAEVA KPAAETTEMQ RELIRTLKEK HTDRRQPGVT EGIQDEIVSR
QQQAEQQAES QNPDRRSSES AAGAAAAASP AELGACQICR RSSGRHSTSS DGGSGAGVGN
GGSHTCHRCR LKTCSRCGSR VSLKPTQSTW LCLNCQRQQE AAREAAREAA TATAQTPPPQ
ELRSRKQRQQ PDEEEQQQQQ RSPRTQQSRP RPTAEMARES TGARASPREL RRQFSLADQQ
HQQQQQSAES PSFEHSGAAA VAAAASAAPS EPWRPTRHST GTGRFYDPGS SQHQHLHPQR
HQYQLQHQQH FRSGRTVSGA ASQMRHQHSL SSSEDDDMLR PLSPDQASWE DPEMETLSER
ELLKKKSVRF GMGSDNDGLS LGRSFEEDSW NSEPLTHKDS GIDTCLSSSS NTLNELSAAK
LQGAAGMSAA AAAAAAASYQ SAKHPVTWQV SKDQRRLIGH MLLKKDCDLD GNMIDLGLKI
IGGKMTPPGR LGAFITKVKP GSAADRVGGL RSGDEVLEWN GNSLKGLTFQ EVYDLLMESK
PERQVELIVQ RPIEDPGYRQ AAARGAFAVR APSEERDRSL SHVPRFPSAS GDALDPGLGT
SPLAATSAMS SSGRLPAGRV QLMLLFDASC SQLLVCLVSA VGLVPPHSST LSNAFAVLCL
LPERNHRRRS RAVSYTNEPT WNQPFTFSPI DEEQLEHTSL HVEVLDYDDM NGCELIGETC
IRLARCNLSG EPASYRLTCP DESDTPTPKY PEHLGDTYRR GRDVVSEPLG YAGGGGGGGG
GGDSLHNRSA SPAIFVDAIG SSLDSSDSLV GPTSGRRHRQ LPQLPESSNT PHRHHQANLR
GSSFDRVASP AASEPSEFSS ALSVQSERLA RSGRAQQQNH QLLRGVSVAG PVASAVAASA
ARRKISSSND GTSSDSGLPG GKSEKSRRAS MGQRFSSLIG RKSSSATNLD NKQRTSFQRS
EEVLPASLAA AGPDPMLSNR PVGAARARYS SQDSEGDVGS MLSLDTAVLS SSAPPPTGSD
SGHLTAFVEG LGPGQLVGRQ VLGTPSLGEI QLGLFNRKGR LEVEVIRARS LYAKKGAKLL
PAPYVKVYLL QGRTCLEKQK TAVTRRTLDP LYQQQLVFLE DFSGKILQVT VWGDYGRMDR
KAFMGICQVL LDDLDLSNIV IGWYKLYPTS SLVHHHHHRQ CSSASSGDIA GASAPSPGPR
//